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When chick N-cadherin is overexpressed in the knockouts via a mosaic model, the defects of cellular orientation and trabeculation were at least partially rescued, suggesting that Numb and Numblike regulate cellular orientation and trabeculation via N-cadherin. Cellular orientation might modulate the directionality of cellular migration, mitotic spindle orientation, and cellular organization during heart morphogenesis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1904684116","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T19:45:12Z","timestamp":1562960712000},"page":"15560-15569","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":31,"title":["Cardiomyocyte orientation modulated by the Numb family proteins\u2013N-cadherin axis is essential for ventricular wall morphogenesis"],"prefix":"10.1073","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8286-9783","authenticated-orcid":false,"given":"Lianjie","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 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