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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Proinflammatory diseases, such as cancer, AIDS, and chronic obstructive pulmonary diseases, are often associated with a progressive loss of skeletal muscle tissue, a syndrome also known as cachexia. Cytokines trigger muscle loss by activating downstream effector pathways, including the ones driven by STAT3 protein. Although high levels of STAT3 protein are required for the onset of muscle wasting, the mechanisms modulating STAT3 expression in cachectic muscles remain elusive. Here we identify the RNA-binding protein HuR and its ability to interfere with miR-330 action as a key promoter of\n                    <jats:italic>STAT3<\/jats:italic>\n                    mRNA translation. Our work identifies the competition between HuR and miR-330 as a mechanism that could be targeted to design novel anticachexia therapies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1905172116","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T20:25:53Z","timestamp":1565641553000},"page":"17261-17270","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":49,"title":["HuR counteracts miR-330 to promote STAT3 translation during inflammation-induced muscle wasting"],"prefix":"10.1073","volume":"116","author":[{"given":"Souad","family":"Mubaid","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer F.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Rosalind and Morris Goodman 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Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cammas","sequence":"additional","affiliation":[{"name":"Cancer Research Centre of Toulouse, INSERM UMR 1037, 31037 Toulouse, France;"},{"name":"Universit\u00e9 Toulouse III Paul Sabatier, 31330 Toulouse, France;"},{"name":"Laboratoire d\u2019Excellence \u201cTOUCAN,\u201d 31037 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Dormoy-Raclet","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre Hospitalier Universitaire de Bordeaux, 33076 Bordeaux Cedex, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Di Marco","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridar V.","family":"Chittur","sequence":"additional","affiliation":[{"name":"College of Nanoscale Sciences, State University of New York (SUNY) Polytechnic Institute, Albany, NY 12203;"},{"name":"College of Engineering, SUNY Polytechnic Institute, Albany, NY 12203"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Tenenbaum","sequence":"additional","affiliation":[{"name":"College of Nanoscale Sciences, State University of New York (SUNY) Polytechnic Institute, Albany, NY 12203;"},{"name":"College of Engineering, SUNY Polytechnic Institute, Albany, NY 12203"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4758-4835","authenticated-orcid":false,"given":"Imed-Eddine","family":"Gallouzi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-014-9915-y"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.04.023"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-2739"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.10.006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70068-8"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.105"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201607052"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.02.009"},{"key":"e_1_3_3_9_2","first-page":"702","article-title":"Inducible nitric oxide synthase (iNOS) in muscle wasting syndrome, sarcopenia, and 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