{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:03:57Z","timestamp":1790618637551,"version":"4.1.0"},"reference-count":70,"publisher":"National Academy of Sciences","issue":"38","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"name":"Branco Weiss Foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/501100007674","name":"A*STAR | Institute of Molecular and Cell Biology","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100007674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation Singapore","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001245","name":"Jeffrey Modell Foundation","doi-asserted-by":"publisher","award":["Ghent University Hospital"],"award-info":[{"award-number":["Ghent University Hospital"]}],"id":[{"id":"10.13039\/100001245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003441","name":"Ghent University Hospital","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100003441","id-type":"DOI","asserted-by":"crossref"}]},{"name":"E-RARe Program","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/100000097","name":"HHS | NIH | National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1TR001866"],"award-info":[{"award-number":["UL1TR001866"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-IAHU-01"],"award-info":[{"award-number":["ANR-10-IAHU-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-LABX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI107508"],"award-info":[{"award-number":["R21AI107508"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French Cancer Institute","award":["2013-1-PL BIO-11-1"],"award-info":[{"award-number":["2013-1-PL BIO-11-1"]}]},{"DOI":"10.13039\/100002350","name":"St. Giles Foundation","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100002350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012007","name":"Rockefeller University","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100012007","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005413","name":"Universit\u00e9 Paris Descartes","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100005413","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shapiro-Silverberg Fund","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/100001461","name":"American Philosophical Society","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100001461","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Amsterdam Academic Alliance","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,9,17]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Recurrent respiratory papillomatosis is a disease caused by the human papillomavirus that leads to growth of warts in the throat. We report 2 brothers with a form of this disease that involves a mutation in the\n                    <jats:italic>NLRP1<\/jats:italic>\n                    gene. This study provides a genetic explanation for our patients\u2019 disease and suggests that other people may suffer from the same genetic disease. It also expands our understanding of diseases caused by mutations in\n                    <jats:italic>NLRP1<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1073\/pnas.1906184116","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T18:59:11Z","timestamp":1567623551000},"page":"19055-19063","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":122,"title":["Homozygous\n                    <i>NLRP1<\/i>\n                    gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis"],"prefix":"10.1073","volume":"116","author":[{"given":"Scott B.","family":"Drutman","sequence":"first","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomeen","family":"Haerynck","sequence":"additional","affiliation":[{"name":"Primary Immune Deficiency Research Laboratory, Department of Internal Diseases and Pediatrics, Centre for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, 9000 Ghent, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin L.","family":"Zhong","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, A*STAR, 138673 Proteos, Singapore;"},{"name":"Laboratory of Human Embryology and Genetics, Institute of Medical Biology, A*STAR, 138648 Immunos, Singapore;"},{"name":"Skin Research Institute of Singapore, 138648 Immunos, Singapore;"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, 636921 Singapore;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hum","sequence":"additional","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Belkaya","sequence":"additional","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Rapaport","sequence":"additional","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Jill","family":"de Jong","sequence":"additional","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Creytens","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ghent University Hospital, 9000 Ghent, Belgium;"},{"name":"Cancer Research Institute Ghent, Ghent University, 9000 Ghent, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Tavernier","sequence":"additional","affiliation":[{"name":"Primary Immune Deficiency Research Laboratory, Department of Internal Diseases and Pediatrics, Centre for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, 9000 Ghent, Belgium;"},{"name":"Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, Flanders Institute for Biotechnology, 9052 Ghent, Belgium;"},{"name":"Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Bonte","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Craniofacial Team, Gent University Hospital, 9000 Ghent, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"De Schepper","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ghent University Hospital, 9000 Ghent, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutte","family":"van der Werff ten Bosch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universitair Ziekenhuis Brussel, 1090 Jette, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazaro","family":"Lorenzo-Diaz","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France;"},{"name":"Imagine Institute, Paris Descartes University, 75006 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Wullaert","sequence":"additional","affiliation":[{"name":"Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium;"},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium;"},{"name":"Center for Inflammation Research, Flanders Institute for Biotechnology, 9052 Ghent, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Bossuyt","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, KU Leuven, 3000 Leuven, Belgium;"},{"name":"Department of Laboratory Medicine, University Hospitals Leuven, 3000 Leuven, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Orth","sequence":"additional","affiliation":[{"name":"Department of Virology, Pasteur Institute, 75015 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent R.","family":"Bonagura","sequence":"additional","affiliation":[{"name":"Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY 11030;"},{"name":"Division of Allergy and Immunology, Department of Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Great Neck, NY 11549;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4020-824X","authenticated-orcid":false,"given":"Vivien","family":"B\u00e9ziat","sequence":"additional","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, 10065;"},{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France;"},{"name":"Imagine Institute, Paris Descartes University, 75006 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Abel","sequence":"additional","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, 10065;"},{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France;"},{"name":"Imagine Institute, Paris Descartes University, 75006 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Jouanguy","sequence":"additional","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, 10065;"},{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France;"},{"name":"Imagine Institute, Paris Descartes University, 75006 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Reversade","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, A*STAR, 138673 Proteos, Singapore;"},{"name":"Laboratory of Human Embryology and Genetics, Institute of Medical Biology, A*STAR, 138648 Immunos, Singapore;"},{"name":"Medical Genetics Department, Ko\u00e7 University School of Medicine, 34450 Istanbul, Turkey;"},{"name":"Reproductive Biology Laboratory, Amsterdam UMC Netherlands, 1105 AZ Amsterdam, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, 10065;"},{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France;"},{"name":"Imagine Institute, Paris Descartes University, 75006 Paris, France;"},{"name":"Pediatric Immunology-Hematology Unit, Necker Hospital for Sick Children, 75015 Paris, France;"},{"name":"HHMI, The Rockefeller University, New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000115"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890120044008"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2010.02619.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.7.743"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2012.03.006"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31816a7135"},{"key":"e_1_3_3_7_2","first-page":"795","article-title":"Rarity of cesarean delivery in cases of juvenile-onset respiratory papillomatosis","volume":"68","author":"Shah K.","year":"1986","unstructured":"K. Shah ., Rarity of cesarean delivery in cases of juvenile-onset respiratory papillomatosis. Obstet. Gynecol. 68, 795\u2013799 (1986).","journal-title":"Obstet. Gynecol."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199805000-00005"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.2826"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24730"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.132"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.12.1275"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.9.976"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003489415608196"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880164"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22953"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099114"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80849-0"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.06.021"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.03.033"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir342"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2012-050886"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.049"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170308"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01222"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2010.02617.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2014.00098"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1578"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180628"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128346"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130592"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198706000-00005"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606460113"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1518646112"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3739"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1808403116"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90358-5"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12283"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003709"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.04.074"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19057"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.311"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.001"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210021"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004350"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2017.12.013"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-101011-155745"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3893"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3089"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71543"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90699"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.01.012"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau1208"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau1330"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02407"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.020"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00987.x"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003536"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017848"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-015-0201-1"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.10.022"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00351"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706314"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1044"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.330"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.01.002"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07734.x"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp698"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1906184116","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1906184116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T04:57:34Z","timestamp":1649825854000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1906184116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,4]]},"references-count":70,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2019,9,17]]}},"alternative-id":["10.1073\/pnas.1906184116"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1906184116","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736558602.793572043","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,4]]},"assertion":[{"value":"2019-09-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}