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In this study, we revealed that the Arid5a protein regulates the adipogenesis and the development of obesity in mice. Arid5a inhibits adipogenesis by suppressing the transcription of peroxisome proliferator activated receptor gamma 2 (Ppar-\u03b32), which is the main facilitator of adipogenesis. Further, we showed adipose tissue homeostasis is maintained by the coordinated activity of Arid5a and Ppar-\u03b32. Our study provides important insights into the novel mechanism of adipose tissue homeostasis.<\/jats:p>","DOI":"10.1073\/pnas.1906712116","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T17:06:04Z","timestamp":1562691964000},"page":"15128-15133","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":34,"title":["Feedback regulation of Arid5a and Ppar-\u03b32 maintains adipose tissue homeostasis"],"prefix":"10.1073","volume":"116","author":[{"given":"Jaya Prakash","family":"Chalise","sequence":"first","affiliation":[{"name":"Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 65-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka 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