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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>erm41<\/jats:italic>\n                    gene is considered the primary mechanism of intrinsic resistance to macrolides in\n                    <jats:italic>Mycobacterium abscessus<\/jats:italic>\n                    . Here we demonstrate that the\n                    <jats:italic>hflX<\/jats:italic>\n                    gene plays a significant and equally important role as\n                    <jats:italic>erm41<\/jats:italic>\n                    . We further describe an unusual mechanism of resistance to macrolide-lincosamide antibiotics mediated by the mycobacterial HflX that likely involves the dissociation of antibiotic-stalled ribosomes. An understanding of the various mechanisms employed by bacteria for resistance to an antibiotic is critical in predicting an effective therapeutic regimen against a pathogenic isolate, and can also inform the development of novel drugs.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1906748117","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T20:36:17Z","timestamp":1577133377000},"page":"629-634","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":55,"title":["Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance"],"prefix":"10.1073","volume":"117","author":[{"given":"Paulami","family":"Rudra","sequence":"first","affiliation":[{"name":"Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley 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