{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:54:58Z","timestamp":1791345298048,"version":"4.3.1"},"reference-count":74,"publisher":"National Academy of Sciences","issue":"46","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K01AR065506"],"award-info":[{"award-number":["K01AR065506"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI135063"],"award-info":[{"award-number":["R01AI135063"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P01AI102852"],"award-info":[{"award-number":["P01AI102852"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Insitute of Health","award":["R01HL127464"],"award-info":[{"award-number":["R01HL127464"]}]},{"name":"National Institute of Healgh","award":["R35HL142281"],"award-info":[{"award-number":["R35HL142281"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,11,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Monocyte to macrophage differentiation is critical to inflammation and resolution of inflammation and can be regulated by high-mobility group box 1 (HMGB1) and HMGB1 plus C1q, respectively. These are 2 evolutionarily old and highly conserved molecules. While HMGB1 causes a positive-feedback loop between the proinflammatory lipid mediator leukotriene B4 (LTB\n                    <jats:sub>4<\/jats:sub>\n                    ) and IRF5, an important regulator of inflammatory macrophage polarization, HMGB1 plus C1q increases production of specialized proresolving lipid mediators (SPMs) lipoxin A4, resolvin D1, and resolvin D2, which prevent IRF5 transcription. As nonresolving inflammation is a common condition, we designed an HMGB1\u2013C1q mimetic peptide that can polarize monocytes to an antiinflammatory phenotype in vitro and in vivo.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1907490116","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T22:24:30Z","timestamp":1569882270000},"page":"23254-23263","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":85,"title":["HMGB1\u2013C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis"],"prefix":"10.1073","volume":"116","author":[{"given":"Tianye","family":"Liu","sequence":"first","affiliation":[{"name":"Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY 11030;"},{"name":"MD\/PhD Program at Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11549;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec","family":"Xiang","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY 11030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY 11030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C.","family":"Doran","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University, New York, NY 10032;"},{"name":"Department of Physiology, Columbia University, New York, NY 10032;"},{"name":"Department of Pathology and Cell Biology, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Tracey","sequence":"additional","affiliation":[{"name":"The Center for Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY 11030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy J.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY 11030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Tabas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University, New York, NY 10032;"},{"name":"Department of Physiology, Columbia University, New York, NY 10032;"},{"name":"Department of Pathology and Cell Biology, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0655-3859","authenticated-orcid":false,"given":"Myoungsun","family":"Son","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY 11030;"},{"name":"MD\/PhD Program at Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11549;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3250-3804","authenticated-orcid":false,"given":"Betty","family":"Diamond","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY 11030;"},{"name":"MD\/PhD Program at Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11549;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.04.005"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.008"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.10.006"},{"key":"e_1_3_3_4_2","first-page":"e679","article-title":"Macrophage polarization in kidney diseases","volume":"2","author":"Tian S.","year":"2015","unstructured":"S. Tian, S. Y. Chen, Macrophage polarization in kidney diseases. Macrophage (Houst.) 2, e679 (2015).","journal-title":"Macrophage (Houst.)"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.39"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1607003113"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13479"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5548.1871"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97945"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97950"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97943"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01400"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805593200"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2133253100"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410851111"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100322"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753425916628618"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-225615"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.10.006"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-719757"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-014-0762-0"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80530-0"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1212753109"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.05.025"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101323"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.074484"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1457"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011531"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120201"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01938"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800226"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1990"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03308"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3829"},{"key":"e_1_3_3_35_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/intimm\/dxy032","article-title":"Regulation and role of the transcription factor IRF5 in innate immune responses and systemic lupus erythematosus","volume":"30","author":"Ban T.","year":"2018","unstructured":"T. Ban, G. R. Sato, T. Tamura, Regulation and role of the transcription factor IRF5 in innate immune responses and systemic lupus erythematosus. Int. Immunol. 30, 529\u2013536 (2018).","journal-title":"Int. Immunol."},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2014.00185"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42410-8"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-217000"},{"key":"e_1_3_3_39_2","first-page":"4805","article-title":"Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis","volume":"62","author":"Huttunen H. J.","year":"2002","unstructured":"H. J. Huttunen, C. Fages, J. Kuja-Panula, A. J. Ridley, H. Rauvala, Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis. Cancer Res. 62, 4805\u20134811 (2002).","journal-title":"Cancer Res."},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.039"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12859"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-015-8705-6"},{"key":"e_1_3_3_43_2","first-page":"252","article-title":"Urine leukotriene E4 levels are elevated in patients with active systemic lupus erythematosus","volume":"19","author":"Hackshaw K. V.","year":"1992","unstructured":"K. V. Hackshaw, N. F. Voelkel, R. B. Thomas, J. Y. Westcott, Urine leukotriene E4 levels are elevated in patients with active systemic lupus erythematosus. J. Rheumatol. 19, 252\u2013258 (1992).","journal-title":"J. Rheumatol."},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-10-76"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.2174\/138945010791320881"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.2174\/157340308784245775"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2019.04.001"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1998.0744"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-3-12"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.12"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.02.009"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5264195"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100225"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.06.018"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027844"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.060"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002795"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141642"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402807"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103478"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1782"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22591"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201500117"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002863200"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.137"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609212200"},{"key":"e_1_3_3_67_2","first-page":"462","article-title":"A pilot study of zileuton, a novel selective 5-lipoxygenase inhibitor, in patients with systemic lupus erythematosus","volume":"22","author":"Hackshaw K. V.","year":"1995","unstructured":"K. V. Hackshaw, Y. Shi, S. R. Brandwein, K. Jones, J. Y. Westcott, A pilot study of zileuton, a novel selective 5-lipoxygenase inhibitor, in patients with systemic lupus erythematosus. J. Rheumatol. 22, 462\u2013468 (1995).","journal-title":"J. Rheumatol."},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12114"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10346"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3842"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25539"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907342107"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.33395"},{"key":"e_1_3_3_74_2","unstructured":"National Research Council Guide for the Care and Use of Laboratory Animals (National Academies Press Washington DC ed. 8 2011)."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1907490116","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1907490116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T10:43:43Z","timestamp":1664534623000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1907490116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,30]]},"references-count":74,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2019,11,12]]}},"alternative-id":["10.1073\/pnas.1907490116"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1907490116","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,30]]},"assertion":[{"value":"2019-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}