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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,9,17]]},"abstract":"<jats:p>\n                    Human cytomegalovirus (HCMV) manipulates many aspects of host cell biology to create an intracellular milieu optimally supportive of its replication and spread. Our study reveals that levels of several components of the purinergic signaling system, including the P2Y2 and P2X5 receptors, are elevated in HCMV-infected fibroblasts. Knockdown and drug treatment experiments demonstrated that P2Y2 enhances the yield of virus, whereas P2X5 reduces HCMV production. The HCMV IE1 protein induces P2Y2 expression; and P2Y2-mediated signaling is important for efficient HCMV gene expression, DNA synthesis, and the production of infectious HCMV progeny. P2Y2 cooperates with the viral UL37x1 protein to regulate cystolic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    levels. P2Y2 also regulates PI3K\/Akt signaling and infected cell motility. Thus, P2Y2 functions at multiple points within the viral replication cycle to support the efficient production of HCMV progeny, and it may facilitate in vivo viral spread through its role in cell migration.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1907562116","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T16:39:21Z","timestamp":1567528761000},"page":"18971-18982","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":29,"title":["P2Y2 purinergic receptor modulates virus yield, calcium homeostasis, and cell motility in human cytomegalovirus-infected cells"],"prefix":"10.1073","volume":"116","author":[{"given":"Saisai","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Shenk","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej T.","family":"Nogalski","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1128\/CMR.13.1.83","article-title":"New strategies for prevention and therapy of cytomegalovirus infection and disease in solid-organ transplant recipients","volume":"13","author":"Sia I. G.","year":"2000","unstructured":"I. G. Sia, R. Patel, New strategies for prevention and therapy of cytomegalovirus infection and disease in solid-organ transplant recipients. Clin. Microbiol. Rev. 13, 83\u2013121 (2000).","journal-title":"Clin. Microbiol. Rev."},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/clinids\/22.3.537","article-title":"Cytomegalovirus infection following liver transplantation: Review of the literature","volume":"22","author":"Kanj S. S.","year":"1996","unstructured":"S. S. Kanj, A. I. Sharara, P. A. Clavien, J. D. Hamilton, Cytomegalovirus infection following liver transplantation: Review of the literature. Clin. Infect. Dis. 22, 537\u2013549 (1996).","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_4_3_2","first-page":"279","article-title":"Human cytomegalovirus end-organ disease is associated with high or low systemic viral load in preemptively treated solid-organ transplant recipients","volume":"35","author":"Gerna G.","year":"2012","unstructured":"G. Gerna ., Human cytomegalovirus end-organ disease is associated with high or low systemic viral load in preemptively treated solid-organ transplant recipients. New Microbiol. 35, 279\u2013287 (2012).","journal-title":"New Microbiol."},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijid.2013.12.010","article-title":"Systematic review of the birth prevalence of congenital cytomegalovirus infection in developing countries","volume":"22","author":"Lanzieri T. M.","year":"2014","unstructured":"T. M. Lanzieri, S. C. Dollard, S. R. Bialek, S. D. Grosse, Systematic review of the birth prevalence of congenital cytomegalovirus infection in developing countries. Int. J. Infect. 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Sci."},{"key":"e_1_3_4_9_2","first-page":"413","article-title":"Receptors for purines and pyrimidines","volume":"50","author":"Ralevic V.","year":"1998","unstructured":"V. Ralevic, G. Burnstock, Receptors for purines and pyrimidines. Pharmacol. Rev. 50, 413\u2013492 (1998).","journal-title":"Pharmacol. Rev."},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.1411571","article-title":"Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C","volume":"258","author":"Nishizuka Y.","year":"1992","unstructured":"Y. Nishizuka, Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607\u2013614 (1992).","journal-title":"Science"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"44638","DOI":"10.1074\/jbc.M203012200","article-title":"Extracellular ATP is an autocrine\/paracrine regulator of hypoxia-induced adventitial fibroblast growth. 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