{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:30:32Z","timestamp":1791354632616,"version":"4.3.1"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"37","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,9,10]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    <jats:sc>l<\/jats:sc>\n                    -Dopa\u2013induced dyskinesia (LID) is a major complication of dopaminergic therapy in Parkinson\u2019s disease. These involuntary movements have been associated with several molecular changes in the striatum, including increased levels of \u0394FosB. However, whether \u0394FosB upregulation plays a major role in the development of the primate LID or is an epiphenomenon of chronic\n                    <jats:sc>l<\/jats:sc>\n                    -Dopa treatment remains unknown. Using transgenic expression of \u0394FosB in the striatum of parkinsonian primates, we show that elevated levels of \u0394FosB lead to LID development in the absence of chronic\n                    <jats:sc>l<\/jats:sc>\n                    -Dopa exposure. The physiological and molecular changes associated with LID are also replicated in this model. These findings suggest that \u0394FosB elevation is responsible for LID generation and that repressing its expression can have therapeutic value.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1907810116","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T17:05:37Z","timestamp":1566925537000},"page":"18664-18672","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":45,"title":["Role of striatal \u0394FosB in\n                    <scp>l<\/scp>\n                    -Dopa\u2013induced dyskinesias of parkinsonian nonhuman primates"],"prefix":"10.1073","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8890-2743","authenticated-orcid":false,"given":"Goichi","family":"Beck","sequence":"first","affiliation":[{"name":"Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329;"},{"name":"Department of Neurology, Osaka University Graduate School of Medicine, 565-0871 Suita, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Singh","sequence":"additional","affiliation":[{"name":"Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"RWJMS Institute for Neurological Therapeutics, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854;"},{"name":"Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa F.","family":"Potts","sequence":"additional","affiliation":[{"name":"Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Min","family":"Woo","sequence":"additional","affiliation":[{"name":"RWJMS Institute for Neurological Therapeutics, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854;"},{"name":"Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun S.","family":"Park","sequence":"additional","affiliation":[{"name":"RWJMS Institute for Neurological Therapeutics, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854;"},{"name":"Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Osaka University Graduate School of Medicine, 565-0871 Suita, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-412X","authenticated-orcid":false,"given":"M. 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