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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,9,10]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    is considered a nosocomial pathogen, usually infecting immunocompromised patients. However, a pathotype of\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    , termed hypervirulent\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    (hv\n                    <jats:italic>Kp<\/jats:italic>\n                    ), has emerged and is spreading throughout the community, causing severe, often fatal, disease in healthy individuals. Moreover, reports on multidrug-resistant hv\n                    <jats:italic>Kp<\/jats:italic>\n                    isolates are increasing in frequency. It is imperative that strategies to combat hv\n                    <jats:italic>Kp<\/jats:italic>\n                    begin immediately to prevent further dissemination of this new class of \u201csuperbugs.\u201d Here, we show that bioconjugate vaccines targeting the capsule of hv\n                    <jats:italic>Kp<\/jats:italic>\n                    can provide immunity and protection against extremely lethal hv\n                    <jats:italic>Kp<\/jats:italic>\n                    strains. Further, we demonstrate that bioconjugation is a promising technology for rapid development of efficacious vaccines against emerging bacterial threats.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1907833116","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T17:05:55Z","timestamp":1566925555000},"page":"18655-18663","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":201,"title":["A promising bioconjugate vaccine against hypervirulent\n                    <i>Klebsiella pneumoniae<\/i>"],"prefix":"10.1073","volume":"116","author":[{"given":"Mario F.","family":"Feldman","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110;"},{"name":"VaxNewMo, St. Louis, MO 63108;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Mayer 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