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During the last 20 y, several so-called selective GC receptor agonistic modulators (SEGRAMs) have been reported and claimed to be less debilitating than GCs while keeping their long-term beneficial anti-inflammatory properties. However, none of these possible SEGRAMs have been fully tested for undesirable detrimental effects that may occur upon long-term therapy in vivo. We now report that the anti-inflammatory compounds CpdX and CpdX-D3 as well as their enantiomers are bona fide \u201charmless\u201d SEGRAMs as, upon 3-mo-long administration to mice, none of the known GC-induced debilitating side effects were observed.<\/jats:p>","DOI":"10.1073\/pnas.1908264116","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T20:06:08Z","timestamp":1561061168000},"page":"14200-14209","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":18,"title":["The glucocorticoid receptor agonistic modulators CpdX and CpdX-D3 do not generate the debilitating effects of synthetic glucocorticoids"],"prefix":"10.1073","volume":"116","author":[{"given":"Guoqiang","family":"Hua","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U1258, 67404 Illkirch, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naimah","family":"Zein","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U1258, 67404 Illkirch, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Paulen","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U1258, 67404 Illkirch, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7861-6046","authenticated-orcid":false,"given":"Pierre","family":"Chambon","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U1258, 67404 Illkirch, France;"},{"name":"University of Strasbourg Institute for Advanced Study, 67404 Illkirch, France;"},{"name":"Coll\u00e8ge de France, 67404 Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.12.004"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164265"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.03.027"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522821113"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524215113"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.12.014"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.04.021"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522826113"},{"key":"e_1_3_3_9_2","first-page":"745","article-title":"Mapracorat, a selective glucocorticoid receptor agonist, causes apoptosis of eosinophils infiltrating the conjunctiva in late-phase experimental ocular allergy","volume":"8","author":"Baiula M.","year":"2014","unstructured":"M. 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