{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:19:47Z","timestamp":1792667987295,"version":"4.5.0"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"1","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["RO1-DC013693"],"award-info":[{"award-number":["RO1-DC013693"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21-AI137947"],"award-info":[{"award-number":["R21-AI137947"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"<jats:p>\n                    Mosquitoes are important vectors of disease and require sources of carbohydrates for reproduction and survival. Unlike host-related behaviors of mosquitoes, comparatively less is understood about the mechanisms involved in nectar-feeding decisions, or how this sensory information is processed in the mosquito brain. Here we show that\n                    <jats:italic>Aedes<\/jats:italic>\n                    spp. mosquitoes, including\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    , are effective pollinators of the\n                    <jats:italic>Platanthera obtusata<\/jats:italic>\n                    orchid, and demonstrate this mutualism is mediated by the orchid\u2019s scent and the balance of excitation and inhibition in the mosquito\u2019s antennal lobe (AL). The\n                    <jats:italic>P. obtusata<\/jats:italic>\n                    orchid emits an attractive, nonanal-rich scent, whereas related\n                    <jats:italic>Platanthera<\/jats:italic>\n                    species\u2014not visited by mosquitoes\u2014emit scents dominated by lilac aldehyde. Calcium imaging experiments in the mosquito AL revealed that nonanal and lilac aldehyde each respectively activate the LC2 and AM2 glomerulus, and remarkably, the AM2 glomerulus is also sensitive to N,N-diethyl-meta-toluamide (DEET), a mosquito repellent. Lateral inhibition between these 2 glomeruli reflects the level of attraction to the orchid scents. Whereas the enriched nonanal scent of\n                    <jats:italic>P. obtusata<\/jats:italic>\n                    activates the LC2 and suppresses AM2, the high level of lilac aldehyde in the other orchid scents inverts this pattern of glomerular activity, and behavioral attraction is lost. These results demonstrate the ecological importance of mosquitoes beyond operating as disease vectors and open the door toward understanding the neural basis of mosquito nectar-seeking behaviors.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1910589117","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T20:36:31Z","timestamp":1577133391000},"page":"708-716","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":141,"title":["The olfactory basis of orchid pollination by mosquitoes"],"prefix":"10.1073","volume":"117","author":[{"given":"Chlo\u00e9","family":"Lahond\u00e8re","sequence":"first","affiliation":[{"name":"Department of Biology, University of Washington, Seattle, WA 98195;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Vinauger","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Washington, Seattle, WA 98195;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo P.","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Washington, Seattle, WA 98195;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella H.","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Washington, Seattle, WA 98195;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy K.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Washington, Seattle, WA 98195;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6853-9884","authenticated-orcid":false,"given":"Omar S.","family":"Akbari","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Riffell","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Washington, Seattle, WA 98195;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"e_1_3_4_1_2","unstructured":"World Health Organization \u201cA global brief on vector-borne diseases\u201d (No. WHO\/DCO\/WHD\/2014.1 WHO Press Geneva Switzerland 2014)."},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3920\/9789086866984_008","article-title":"Host finding by female mosquitoes: mechanisms of orientation to host odours and other cues","volume":"2010","author":"Card\u00e9 R. 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