{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:14:19Z","timestamp":1792602859393,"version":"4.5.0"},"reference-count":71,"publisher":"National Academy of Sciences","issue":"1","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR064551"],"award-info":[{"award-number":["R01AR064551"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16POST29750004"],"award-info":[{"award-number":["16POST29750004"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>This work shows that increased muscle-derived glial cell line-derived neurotrophic factor (GDNF) acting through its receptor GDNF family receptor \u03b11 on primary group III\/IV muscle afferents modulates both nociception and the cardiovascular response to exercise. Importantly, unilateral ischemic muscle injuries not only produce pain-related behaviors in the affected limb, but they also affect sympathetic reflexes systemically. This dual function of primary muscle afferents under ischemic conditions potentially explains why patients with disorders such as sickle cell anemia or peripheral vascular disease concurrently report pain and altered exercise pressor reflexes. Results further highlight the potential use of localized anti-GDNF antibodies as a therapeutic option for these clinical conditions.<\/jats:p>","DOI":"10.1073\/pnas.1910905116","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T17:15:58Z","timestamp":1576602958000},"page":"698-707","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":31,"title":["A dual role for peripheral GDNF signaling in nociception and cardiovascular reflexes in the mouse"],"prefix":"10.1073","volume":"117","author":[{"given":"Luis F.","family":"Queme","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Division of Pain Management, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex A.","family":"Weyler","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Division of Pain Management, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elysia R.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Division of Pain Management, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renita C.","family":"Hudgins","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Division of Pain Management, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4700-096X","authenticated-orcid":false,"given":"Michael P.","family":"Jankowski","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Division of Pain Management, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"},{"name":"Center for Understanding Pediatric Pain, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"},{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,12,17]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01067.2012"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-003-0057-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009887"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2013.075812"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.057539"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.51.3.400"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-002-0059-1"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01344.2007"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00328.2009"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-1-35"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.3.644"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00743.2007"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.09.003"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2856-15.2016"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00141.2010"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2014.09.003"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4582-15.2016"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001094"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00612.2010"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.09.029"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-9055-4"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.09.038"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.06.027"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.07.004"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00774.2010"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.217851"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-7-60"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.04.033"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3803-09.2010"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.006"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.12.020"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4863-05.2006"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2013.00411.x"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.06.011"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.249235"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80966-6"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00247"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X13666170804165928"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.11.028"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.12.003"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.08.026"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3474-08.2009"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00419"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2195-10.2010"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.10.042"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203799"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.1231"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(03)00140-4"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/365855a0"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300546200"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00288.2015"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00623.2008"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00762.2013"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23512"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981221)402:3<303::AID-CNE2>3.0.CO;2-I"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.10.021"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00195.2015"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178353"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201103-0537OC"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00557-X"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnw007"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.064"},{"key":"e_1_3_3_63_2","author":"National Research Council","year":"2011","unstructured":"National Research Council, Guide for the Care and Use of Laboratory Animals (National Academies Press, Washington, DC, ed. 8, 2011).","journal-title":"Guide for the Care and Use of Laboratory Animals"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3643-04.2004"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1080\/08990220500420475"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.079483"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00231.2002"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00991.2004"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.12.003"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00064.2005"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.02.015"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1910905116","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1910905116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T05:21:11Z","timestamp":1649827271000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1910905116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,17]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,7]]}},"alternative-id":["10.1073\/pnas.1910905116"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1910905116","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/627521","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,17]]},"assertion":[{"value":"2019-12-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}