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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,3,24]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Antibodies against neuronal receptors and synaptic proteins are associated with a group of ill-defined central nervous system (CNS) autoimmune diseases named autoimmune encephalitides (AE), characterized by an abrupt onset of seizures and movement and psychiatric deficits. How these antibodies enter the brain to trigger neuroinflammation, and how they affect the function of neural circuits, remains poorly understood. Here, we demonstrate that Th17 lymphocytes are critical for entry of autoantibodies into the CNS, persistent microglia activation, and neurophysiological deficits in odor processing, in a mouse model of postinfectious autoimmune encephalitis triggered by multiple infections with group A\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    . Our findings emphasize the critical role that Th17 lymphocytes play in disease pathogenesis to impair CNS function in AE syndromes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1911097117","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T20:15:58Z","timestamp":1583957758000},"page":"6708-6716","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":80,"title":["Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis"],"prefix":"10.1073","volume":"117","author":[{"given":"Maryann P.","family":"Platt","sequence":"first","affiliation":[{"name":"Graduate Program in Neurobiology and Behavior, Columbia University Irving Medical Center, New York, NY 10032;"},{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Bolding","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Duke University Medical Center, Durham, NC 27708;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte R.","family":"Wayne","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032;"},{"name":"Integrated Program in Cellular, Molecular, and Biomedical Studies, Columbia University Irving Medical Center, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Cutforth","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Franks","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Duke University Medical Center, Durham, NC 27708;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dritan","family":"Agalliu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032;"},{"name":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1708712"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.10.016"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12553"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00442"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01101"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.GPP3-0045-2018"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.09.071"},{"key":"e_1_3_3_8_2","unstructured":"G. Orefici F. Cardona C. J. Cox M. W. Cunningham \u201cPediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS)\u201d in Streptococcus pyogenes: Basic Biology to Clinical Manifestations J. J. Ferretti D. L. Stevens V. A. Fischetti Eds. (University of Oklahoma Oklahoma City OK 2016). https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK333433\/."},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1176\/ajp.155.2.264","article-title":"Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: Clinical description of the first 50 cases","volume":"155","author":"Swedo S. E.","year":"1998","unstructured":"S. E. Swedo ., Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: Clinical description of the first 50 cases. Am. J. Psychiatry 155, 264\u2013271 (1998).","journal-title":"Am. J. 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