{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:15:13Z","timestamp":1790856913996,"version":"4.1.0"},"reference-count":34,"publisher":"National Academy of Sciences","issue":"20","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,9,25]]},"abstract":"<jats:p>\n                    We have reported that normal human salivary gland-derived\n epithelial cells exclusively express keratinocyte growth factor\n receptor (KGFR). In the process of malignant transformation of human\n salivary gland tumors, KGFR gene expression disappeared concomitantly\n with the\n                    <jats:italic>de novo<\/jats:italic>\n                    expression of the fibroblast growth\n factor receptor 1 (FGFR1) and FGFR4 genes. In the present study, we\n introduced wild-type KGFR cDNA or chimeric KGFR\/FGFR1 cDNA, which\n encoded the extracellular domain of KGFR and the intracellular domain\n of FGFR1, into the HSY human salivary adenocarcinoma cell line. The\n KGFR tyrosine kinase suppressed the activity of FGF receptor substrate\n 2 (FRS2) and inhibited the growth of HSY by inducing differentiation\n and apoptosis\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in\n vivo<\/jats:italic>\n                    . Our results provided significant insight into the\n mechanism of KGFR tumor suppression and suggest that KGFR gene therapy\n might be a viable method of inhibiting human salivary adenocarcinoma\n growth.\n                  <\/jats:p>","DOI":"10.1073\/pnas.191377098","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:34:10Z","timestamp":1027679650000},"page":"11336-11340","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":75,"title":["Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis"],"prefix":"10.1073","volume":"98","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Molecular Oral Medicine and Maxillofacial Surgery 1,\r Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-Ku,\r Hiroshima 734-8553, Japan; National Stem Cell Resource,\r American Type Culture Collection, Manassas, VA 20110-2209;\r Central Research Laboratories, ZERIA Pharmaceutical\r Co., Ageo 360-0111, Japan; and Center for Cancer Biology\r and Nutrition, Institute of Bioscience and Technology, Texas A &amp; M\r University System Health Science Center, Houston, TX 77030-3303"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Oral Medicine and Maxillofacial Surgery 1,\r Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-Ku,\r Hiroshima 734-8553, Japan; National Stem Cell Resource,\r American Type Culture Collection, Manassas, VA 20110-2209;\r Central Research Laboratories, ZERIA Pharmaceutical\r Co., Ageo 360-0111, Japan; and Center for Cancer Biology\r and Nutrition, Institute of Bioscience and Technology, Texas A &amp; M\r University System Health Science Center, Houston, TX 77030-3303"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Toratani","sequence":"additional","affiliation":[{"name":"Department of Molecular Oral Medicine and Maxillofacial Surgery 1,\r Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-Ku,\r Hiroshima 734-8553, Japan; National Stem Cell Resource,\r American Type Culture Collection, Manassas, VA 20110-2209;\r Central Research Laboratories, ZERIA Pharmaceutical\r Co., Ageo 360-0111, Japan; and Center for Cancer Biology\r and Nutrition, Institute of Bioscience and Technology, Texas A &amp; M\r University System Health Science Center, Houston, TX 77030-3303"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Denry","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Molecular Oral Medicine and Maxillofacial Surgery 1,\r Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-Ku,\r Hiroshima 734-8553, Japan; National Stem Cell Resource,\r American Type Culture Collection, Manassas, VA 20110-2209;\r Central Research Laboratories, ZERIA Pharmaceutical\r Co., Ageo 360-0111, Japan; and Center for Cancer Biology\r and Nutrition, Institute of Bioscience and Technology, Texas A &amp; M\r University System Health Science Center, Houston, TX 77030-3303"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Molecular Oral Medicine and Maxillofacial Surgery 1,\r Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-Ku,\r Hiroshima 734-8553, Japan; National Stem Cell Resource,\r American Type Culture Collection, Manassas, VA 20110-2209;\r Central Research Laboratories, ZERIA Pharmaceutical\r Co., Ageo 360-0111, Japan; and Center for Cancer Biology\r and Nutrition, Institute of Bioscience and Technology, Texas A &amp; M\r University System Health Science Center, Houston, TX 77030-3303"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wallace L.","family":"McKeehan","sequence":"additional","affiliation":[{"name":"Department of Molecular Oral Medicine and Maxillofacial Surgery 1,\r Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-Ku,\r Hiroshima 734-8553, Japan; National Stem Cell Resource,\r American Type Culture Collection, Manassas, VA 20110-2209;\r Central Research Laboratories, ZERIA Pharmaceutical\r Co., Ageo 360-0111, Japan; and Center for Cancer Biology\r and Nutrition, Institute of Bioscience and Technology, Texas A &amp; M\r University System Health Science Center, Houston, TX 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