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However, the molecular mechanisms enabling probabilistic bet hedging have remained elusive. Here, we find that the human herpesvirus cytomegalovirus\u2014a major cause of birth defects and transplant failures\u2014utilizes stochastic variability in the abundance of a protein packaged into individual viral particles to enable probabilistic bet hedging between alternate viral states.<\/jats:p>","DOI":"10.1073\/pnas.1914430117","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T20:26:26Z","timestamp":1594067186000},"page":"17240-17248","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":16,"title":["A molecular mechanism for probabilistic bet hedging and its role in viral latency"],"prefix":"10.1073","volume":"117","author":[{"given":"Sonali","family":"Chaturvedi","sequence":"first","affiliation":[{"name":"Gladstone Institute for Virology and Immunology, Gladstone|University of California, San Francisco Center for Cell Circuitry, San Francisco, CA 94158;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Klein","sequence":"additional","affiliation":[{"name":"Gladstone Institute for Virology and Immunology, Gladstone|University of California, San Francisco Center for Cell Circuitry, San Francisco, CA 94158;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Vardi","sequence":"additional","affiliation":[{"name":"Gladstone Institute for Virology and Immunology, Gladstone|University of California, San Francisco Center for Cell Circuitry, San Francisco, CA 94158;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Bolovan-Fritts","sequence":"additional","affiliation":[{"name":"Gladstone Institute for Virology and Immunology, Gladstone|University of California, San Francisco Center for Cell Circuitry, San Francisco, CA 94158;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2207-9664","authenticated-orcid":false,"given":"Marie","family":"Wolf","sequence":"additional","affiliation":[{"name":"Gladstone Institute for Virology and Immunology, Gladstone|University of California, San Francisco Center for Cell Circuitry, San Francisco, CA 94158;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Du","sequence":"additional","affiliation":[{"name":"Gladstone Institute for Virology and Immunology, Gladstone|University of California, San Francisco Center for Cell Circuitry, San Francisco, CA 94158;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luwanika","family":"Mlera","sequence":"additional","affiliation":[{"name":"Department of Cell &amp; 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