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Many viruses evade T cell control by using genes that subvert MHC-I presentation on infected cells. Here we shift this paradigm and show that viral proteins that block the effector branch of T cells are more efficient for T cell evasion than MHC-I downregulation. The block of signaling in infected target cells at the level of caspase-8 as a crucial convergence point of death-receptor and perforine\/granzyme pathways in the viral evasion of cytotoxic T cells. We show that these principles apply in the clinically relevant HCMV infection and in the biologically relevant in vivo context, using the MCMV experimental model.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1914667117","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T17:50:29Z","timestamp":1590169829000},"page":"12961-12968","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-4257","authenticated-orcid":false,"given":"M. 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