{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:23:02Z","timestamp":1793298182811,"version":"4.5.0"},"reference-count":24,"publisher":"National Academy of Sciences","issue":"49","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100001395","name":"Wisconsin Alumni Research Foundation","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100001395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,12,3]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The primary source of vitamin D in man is production in the skin following exposure to sunlight or artificially produced ultraviolet (UV) light. Despite the importance of this source, the mechanisms surrounding the transport of cutaneous vitamin D into the circulation have not been clearly defined. We have examined the vitamin D response to UVB in mutant mice lacking vitamin D binding protein (DBP). We have shown that in the absence of DBP, UVB does not correct vitamin D deficiency. Further, injection of small amounts of recombinant DBP to DBP\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice restores the response to vitamin D produced in skin. These results demonstrate a requirement for DBP in the utilization of vitamin D produced in the epidermis by UV light.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1915442116","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T19:54:16Z","timestamp":1574279656000},"page":"24527-24532","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":31,"title":["Vitamin D binding protein is required to utilize skin-generated vitamin D"],"prefix":"10.1073","volume":"116","author":[{"given":"Elizabeth G.","family":"Duchow","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Wisconsin\u2013Madison, Madison, WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy E.","family":"Cooke","sequence":"additional","affiliation":[{"name":"Department of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 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