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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,12,17]]},"abstract":"<jats:p>The oncogenic gammaherpesviruses, including human Epstein\u2013Barr virus (EBV), human Kaposi\u2019s sarcoma-associated herpesvirus (KSHV), and murine gammaherpesvirus 68 (MHV68, \u03b3HV68, MuHV-4) establish life-long latency in circulating B cells. The precise determinants that mediate in vivo gammaherpesvirus latency and tumorigenesis remain unclear. The EBV-encoded RNAs (EBERs) are among the first noncoding RNAs ever identified and have been the subject of decades of studies; however, their biological roles during in vivo infection remain unknown. Herein, we use a series of refined virus mutants to define the active isoform of MHV68 noncoding RNA TMER4 and demonstrate that EBV EBER1 functionally conserves this activity in vivo to promote egress of infected B cells from lymph nodes into peripheral circulation.<\/jats:p>","DOI":"10.1073\/pnas.1915752116","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T17:06:00Z","timestamp":1575392760000},"page":"25392-25394","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":24,"title":["Epstein\u2013Barr virus EBER1 and murine gammaherpesvirus TMER4 share conserved in vivo function to promote B cell egress and dissemination"],"prefix":"10.1073","volume":"116","author":[{"given":"Brett A.","family":"Hoffman","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics &amp; Microbiology, University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics &amp; Microbiology, University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics &amp; Microbiology, University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-1642","authenticated-orcid":false,"given":"Scott A.","family":"Tibbetts","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics &amp; Microbiology, University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032015"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2018.09.005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2349"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.259077.115"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00071-19"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.2.805"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.32.1.8-18.1979"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00981-14"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.8.5894-5904.1997"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-78-7-1675"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.1873910"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth746"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-1-149"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.12.016"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00105-15"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00026-16"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355838299981256"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.15.4789"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02572-09"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01324"},{"key":"e_1_3_3_21_2","unstructured":"EBER1 sequence derived from \u201cHuman herpesvirus 4 complete wild type genome.\u201d NCBI GenBank. https:\/\/www.ncbi.nlm.nih.gov\/nuccore\/AJ507799.2. 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