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Most fungal cell walls expose chitin, which is recognized by the human immune system, but\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    is one of the few species that instead exposes chitosan, the deacetylated form of chitin. Chitosan is produced by chitin synthases and chitin deacetylases, the latter acting on chitin as a substrate. Here we describe the detailed functional analysis of CnCda4, a chitin deacetylase with unusual subsite specificity resulting in a preference for chitosan rather than chitin. By testing the effect of CnCda4 deacetylation products on human peripheral blood-derived macrophages, we show that the enzyme probably helps the pathogen to evade the host immune system by further deacetylating exposed chitosans.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1915798117","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T20:25:42Z","timestamp":1580761542000},"page":"3551-3559","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":52,"title":["Unique subsite specificity and potential natural function of a chitosan deacetylase from the human pathogen\n                    <i>Cryptococcus neoformans<\/i>"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1575-7423","authenticated-orcid":false,"given":"Lea","family":"Hembach","sequence":"first","affiliation":[{"name":"Institute for Biology and Biotechnology of Plants, University of M\u00fcnster, 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