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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,2,18]]},"abstract":"<jats:p>\n                    The facultative intracellular pathogen\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    uses an actin-based motility process to spread within human tissues. Filamentous actin from the human cell forms a tail behind bacteria, propelling microbes through the cytoplasm. Motile bacteria remodel the host plasma membrane into protrusions that are internalized by neighboring cells. A critical unresolved question is whether generation of protrusions by\n                    <jats:italic>Listeria<\/jats:italic>\n                    involves stimulation of host processes apart from actin polymerization. Here we demonstrate that efficient protrusion formation in polarized epithelial cells involves bacterial subversion of host exocytosis. Confocal microscopy imaging indicated that exocytosis is up-regulated in protrusions of\n                    <jats:italic>Listeria<\/jats:italic>\n                    in a manner that depends on the host exocyst complex. Depletion of components of the exocyst complex by RNA interference inhibited the formation of\n                    <jats:italic>Listeria<\/jats:italic>\n                    protrusions and subsequent cell-to-cell spread of bacteria. Additional genetic studies indicated important roles for the exocyst regulators Rab8 and Rab11 in bacterial protrusion formation and spread. The secreted\n                    <jats:italic>Listeria<\/jats:italic>\n                    virulence factor InlC associated with the exocyst component Exo70 and mediated the recruitment of Exo70 to bacterial protrusions. Depletion of exocyst proteins reduced the length of\n                    <jats:italic>Listeria<\/jats:italic>\n                    protrusions, suggesting that the exocyst complex promotes protrusion elongation. Collectively, these results demonstrate that\n                    <jats:italic>Listeria<\/jats:italic>\n                    exploits host exocytosis to stimulate intercellular spread of bacteria.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1916676117","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T20:29:52Z","timestamp":1580761792000},"page":"3789-3796","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":41,"title":["<i>Listeria monocytogenes<\/i>\n                    exploits host exocytosis to promote cell-to-cell spread"],"prefix":"10.1073","volume":"117","author":[{"given":"Georgina C.","family":"Dowd","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago, 9054 Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Mortuza","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago, 9054 Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manmeet","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago, 9054 Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoan","family":"Van Ngo","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago, 9054 Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago, 9054 Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano A.","family":"Rigano","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago, 9054 Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Ireton","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago, 9054 Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"130079","DOI":"10.1098\/rsob.130079","article-title":"Molecular mechanisms of cell-cell spread of intracellular bacterial pathogens","volume":"3","author":"Ireton K.","year":"2013","unstructured":"K. Ireton, Molecular mechanisms of cell-cell spread of intracellular bacterial pathogens. Open Biol. 3, 130079 (2013).","journal-title":"Open Biol."},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mib.2016.11.007","article-title":"Actin-based motility and cell-to-cell spread of bacterial pathogens","volume":"35","author":"Lamason R. L.","year":"2017","unstructured":"R. L. Lamason, M. D. Welch, Actin-based motility and cell-to-cell spread of bacterial pathogens. Curr. Opin. Microbiol. 35, 48\u201357 (2017).","journal-title":"Curr. Opin. Microbiol."},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1126\/science.1059975","article-title":"Mechanism of actin-based motility","volume":"292","author":"Pantaloni D.","year":"2001","unstructured":"D. Pantaloni, C. Le Clainche, M. F. Carlier, Mechanism of actin-based motility. 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Cell Sci."},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1083\/jcb.146.6.1333","article-title":"Listeria monocytogenes exploits normal host cell processes to spread from cell to cell","volume":"146","author":"Robbins J. R.","year":"1999","unstructured":"J. R. Robbins ., Listeria monocytogenes exploits normal host cell processes to spread from cell to cell. J. Cell Biol. 146, 1333\u20131350 (1999).","journal-title":"J. Cell Biol."},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/ncb1964","article-title":"The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria","volume":"11","author":"Rajabian T.","year":"2009","unstructured":"T. Rajabian ., The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria. Nat. Cell Biol. 11, 1212\u20131218 (2009).","journal-title":"Nat. Cell Biol."},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.str.2013.10.017","article-title":"Structural details of human tuba recruitment by InlC of Listeria monocytogenes elucidate bacterial cell-cell spreading","volume":"22","author":"Polle L.","year":"2014","unstructured":"L. Polle, L. A. Rigano, R. Julian, K. Ireton, W. D. Schubert, Structural details of human tuba recruitment by InlC of Listeria monocytogenes elucidate bacterial cell-cell spreading. Structure 22, 304\u2013314 (2014).","journal-title":"Structure"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/cmi.12260","article-title":"Listeria monocytogenes antagonizes the human GTPase Cdc42 to promote bacterial spread","volume":"16","author":"Rigano L. A.","year":"2014","unstructured":"L. A. Rigano, G. C. Dowd, Y. Wang, K. Ireton, Listeria monocytogenes antagonizes the human GTPase Cdc42 to promote bacterial spread. Cell. 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Ryan, The use of pHluorins for optical measurements of presynaptic activity. Biophys. J. 79, 2199\u20132208 (2000).","journal-title":"Biophys. J."},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1523\/JNEUROSCI.3398-07.2008","article-title":"Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin","volume":"28","author":"Frischknecht R.","year":"2008","unstructured":"R. Frischknecht, A. Fejtova, M. Viesti, A. Stephan, P. Sonderegger, Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. J. Neurosci. 28, 1568\u20131579 (2008).","journal-title":"J. Neurosci."},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"13682","DOI":"10.1523\/JNEUROSCI.2300-11.2011","article-title":"Surface traffic of dendritic CaV1.2 calcium channels in hippocampal neurons","volume":"31","author":"Di Biase V.","year":"2011","unstructured":"V. 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Perrais, Recycling endosomes undergo rapid closure of a fusion pore on exocytosis in neuronal dendrites. J. Neurosci. 34, 11106\u201311118 (2014).","journal-title":"J. Neurosci."},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/tra.12418","article-title":"Rab11 regulates the mast cell exocytic response","volume":"17","author":"Wilson J. D.","year":"2016","unstructured":"J. D. Wilson, S. A. Shelby, D. Holowka, B. Baird, Rab11 regulates the mast cell exocytic response. Traffic 17, 1027\u20131041 (2016).","journal-title":"Traffic"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41467-017-00646-w","article-title":"Novel ecto-tagged integrins reveal their trafficking in live cells","volume":"8","author":"Huet-Calderwood C.","year":"2017","unstructured":"C. Huet-Calderwood ., Novel ecto-tagged integrins reveal their trafficking in live cells. Nat. Commun. 8, 570 (2017).","journal-title":"Nat. Commun."},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nmeth.1220","article-title":"Lifeact: A versatile marker to visualize F-actin","volume":"5","author":"Riedl J.","year":"2008","unstructured":"J. Riedl ., Lifeact: A versatile marker to visualize F-actin. Nat. Methods 5, 605\u2013607 (2008).","journal-title":"Nat. Methods"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"e1900056","DOI":"10.1002\/bies.201900056","article-title":"The exocyst: Dynamic machine or static tethering complex?","volume":"41","author":"Nishida-Fukuda H.","year":"2019","unstructured":"H. Nishida-Fukuda, The exocyst: Dynamic machine or static tethering complex? 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Cell Biol."},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.cub.2012.05.055","article-title":"Exo70 stimulates the Arp2\/3 complex for lamellipodia formation and directional cell migration","volume":"22","author":"Liu J.","year":"2012","unstructured":"J. Liu ., Exo70 stimulates the Arp2\/3 complex for lamellipodia formation and directional cell migration. Curr. Biol. 22, 1510\u20131515 (2012).","journal-title":"Curr. Biol."},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ncb2106","article-title":"A molecular network for de novo generation of the apical surface and lumen","volume":"12","author":"Bryant D. M.","year":"2010","unstructured":"D. M. Bryant ., A molecular network for de novo generation of the apical surface and lumen. Nat. Cell Biol. 12, 1035\u20131045 (2010).","journal-title":"Nat. Cell Biol."},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"e12768","DOI":"10.1111\/cmi.12768","article-title":"A role for host cell exocytosis in InlB-mediated internalisation of Listeria monocytogenes","volume":"19","author":"Van Ngo H.","year":"2017","unstructured":"H. Van Ngo, M. Bhalla, D. Y. Chen, K. Ireton, A role for host cell exocytosis in InlB-mediated internalisation of Listeria monocytogenes. Cell Microbiol. 19, e12768 (2017).","journal-title":"Cell Microbiol."},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1242\/jcs.186213","article-title":"Staphylococcus aureus recruits Cdc42GAP through recycling endosomes and the exocyst to invade human endothelial cells","volume":"129","author":"Rauch L.","year":"2016","unstructured":"L. Rauch ., Staphylococcus aureus recruits Cdc42GAP through recycling endosomes and the exocyst to invade human endothelial cells. J. Cell Sci. 129, 2937\u20132949 (2016).","journal-title":"J. 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Biol. 20, 1316\u20131320 (2010).","journal-title":"Curr. Biol."},{"key":"e_1_3_4_47_2","unstructured":"D. C. Dowd . Listeria monocytogenes exploits host exocytosis to promote cell-to-cell spread. Zenodo. https:\/\/zenodo.org\/deposit\/3614677. 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