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These channels are formed by four pore-forming \u03b1 subunits whose biophysical and pharmacological properties are modulated by regulatory \u03b2 and \u03b3 subunits. LINGO1 is a protein, previously shown to be upregulated in both Parkinson\u2019s disease and Essential Tremor. Consequently, we investigated its effects on BK channels and demonstrate that LINGO1 associates with these channels in human cerebellum. LINGO1 causes BK channels to inactivate and to open at more negative potentials. Furthermore, coexpression of BK with LINGO1 also led to a reduction in BK channels in the membrane. Our data support the idea that LINGO1 is a regulatory subunit of BK channels.<\/jats:p>","DOI":"10.1073\/pnas.1916715117","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T20:24:55Z","timestamp":1578947095000},"page":"2194-2200","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":70,"title":["LINGO1 is a regulatory subunit of large conductance, Ca\n                    <sup>2+<\/sup>\n                    -activated potassium channels"],"prefix":"10.1073","volume":"117","author":[{"given":"Srikanth","family":"Dudem","sequence":"first","affiliation":[{"name":"Smooth Muscle Research Centre, Dundalk Institute of Technology, Louth A81 K584, Ireland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roddy J.","family":"Large","sequence":"additional","affiliation":[{"name":"Smooth Muscle Research Centre, Dundalk Institute of Technology, Louth A81 K584, 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