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Recent studies have identified a population of programmed cell death 1 (PD-1+) stemlike CD8 T cells that provide the proliferative burst after PD-1\u2013directed immunotherapy. In this study, we have examined the migratory properties of these stemlike CD8 T cells using the mouse model of chronic lymphocytic choriomeningitis virus infection. We show that these quiescent stemlike CD8 T cells do not circulate and are resident in lymphoid tissues, providing a protective niche for their maintenance during chronic infection. These results raise important questions regarding the role of specialized niches within lymphoid tissues and for developing new immunotherapeutic approaches targeting these PD-1+ stemlike CD8 T cells.<\/jats:p>","DOI":"10.1073\/pnas.1917298117","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T19:55:11Z","timestamp":1581105311000},"page":"4292-4299","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":124,"title":["PD-1+ stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection"],"prefix":"10.1073","volume":"117","author":[{"given":"Se Jin","family":"Im","sequence":"first","affiliation":[{"name":"Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322;"},{"name":"Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322;"},{"name":"Department of Immunology, Sungkyunkwan University School of Medicine, Suwon 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