{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:59:39Z","timestamp":1792051179013,"version":"4.4.0"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"14","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P29551"],"award-info":[{"award-number":["P29551"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P30800"],"award-info":[{"award-number":["P30800"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["I2738"],"award-info":[{"award-number":["I2738"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,4,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Although sequencing of the human genome was completed years ago, we still do not know about the physiological significance of thousands of predicted proteins, particularly of predicted membrane proteins. On the other hand, for approximately 100 human enzymes, no coding gene is known even though their enzymatic reaction has been well characterized. In this work, we assign one of those predicted membrane proteins (transmembrane protein 189; TMEM189) to one of the enzymatic reactions with an uncharacterized gene (plasmanylethanolamine desaturase). This enzyme catalyzes the final step in the biosynthesis of plasmalogens, an abundant class of glycerophospholipids that is depleted in such diseases as Alzheimer\u2019s. Our findings enable interpretation of the previously characterized impaired growth phenotype of\n                    <jats:italic>Tmem189<\/jats:italic>\n                    -deficient mice.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1917461117","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T18:49:24Z","timestamp":1585075764000},"page":"7792-7798","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":133,"title":["The\n                    <i>TMEM189<\/i>\n                    gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1948-3391","authenticated-orcid":false,"given":"Ernst R.","family":"Werner","sequence":"first","affiliation":[{"name":"Institute of Biological Chemistry, Biocenter, Medical University of Innsbruck, A-6020 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Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Golderer","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Biocenter, Medical University of Innsbruck, A-6020 Innsbruck, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Werner-Felmayer","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Biocenter, Medical University of Innsbruck, A-6020 Innsbruck, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-0993","authenticated-orcid":false,"given":"Raphael A.","family":"Zoeller","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Hulo","sequence":"additional","affiliation":[{"name":"Institute of Genetics and 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