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Genomic analysis identified a single-nucleotide polymorphism that results in a premature stop in translation of the lipid A acyltransferase\n                    <jats:italic>pagP<\/jats:italic>\n                    , resulting in synthesis of a stealthy, hypoacylated lipid A structure absent in other Yersiniaceae. This provides evidence of lipid A as a crucial determinant in\n                    <jats:italic>Y. pestis<\/jats:italic>\n                    infectivity, pathogenesis, and host innate immune evasion and represents one of the earliest identified adaptations of\n                    <jats:italic>Y. pestis<\/jats:italic>\n                    from\n                    <jats:italic>Yersinia pseudotuberculosis<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1073\/pnas.1917504117","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T20:26:32Z","timestamp":1598905592000},"page":"22984-22991","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":34,"title":["Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in\n                    <i>Yersinia pestis<\/i>"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2076-3665","authenticated-orcid":false,"given":"Courtney E.","family":"Chandler","sequence":"first","affiliation":[{"name":"Department of Microbial Pathogenesis, University of Maryland, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9440-5011","authenticated-orcid":false,"given":"Erin M.","family":"Harberts","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, University of Maryland, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, University of Maryland, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iyarit","family":"Thaipisuttikul","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 10700;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0460-0380","authenticated-orcid":false,"given":"Jace W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-8070","authenticated-orcid":false,"given":"Adeline M.","family":"Hajjar","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason W.","family":"Sahl","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8045-8200","authenticated-orcid":false,"given":"David R.","family":"Goodlett","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, University of Maryland, Baltimore, MD 21201;"},{"name":"International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland 80-822;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7855-9208","authenticated-orcid":false,"given":"Aaron C.","family":"Pride","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, University of Texas, Austin, TX 78712;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Rasko","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6134-1800","authenticated-orcid":false,"given":"M. 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