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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,8,11]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Planar cell polarization, PCP, describes a form of organization where every cell within a group acquires the same planar characteristics, whether it is orientation of cell division, direction of migration, or localization of a cellular structure. PCP is essential for correct organization of cells into tissues and building a proper body plan. Here we use\n                    <jats:italic>Hydra<\/jats:italic>\n                    , an organism with a single axis of symmetry and a very simple body plan to investigate the function of the cell adhesion molecules Fat-like and Dachsous. We show that\n                    <jats:italic>Hydra<\/jats:italic>\n                    Fat-like and Dachsous are planar polarized, providing a demonstration of planar polarization of proteins in a nonbilaterian organism. We also discover roles for\n                    <jats:italic>Hydra<\/jats:italic>\n                    Fat-like in cell adhesion, spindle orientation, and tissue organization.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1917570117","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T17:51:41Z","timestamp":1597168301000},"page":"19310-19320","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":19,"title":["Ancestral roles of atypical cadherins in planar cell polarity"],"prefix":"10.1073","volume":"117","author":[{"given":"Maria","family":"Brooun","sequence":"first","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Sinai Health System, Toronto, ON M5G 1X5, 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