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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,5,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Autism is a poorly understood brain disorder of childhood onset. It is characterized by social impairments and diagnosed behaviorally. Early diagnosis fosters better developmental outcomes through behavioral intervention. However, long clinic wait times to undergo behavioral evaluation contribute to delayed diagnoses and treatments. Emerging evidence indicates that low cerebrospinal fluid concentration of the \u201csocial\u201d neuropeptide vasopressin is a marker of social impairment in children with autism. Here we report that cerebrospinal fluid vasopressin concentration is significantly lower in newborns diagnosed with autism later in childhood. These preliminary findings suggest that a biomarker of autism may be present before behavioral symptoms emerge. If replicated, this approach could be useful for assessing autism risk and facilitating early intervention in high-risk individuals.<\/jats:p>","DOI":"10.1073\/pnas.1919050117","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T20:25:22Z","timestamp":1588019122000},"page":"10609-10613","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":63,"title":["Neonatal CSF vasopressin concentration predicts later medical record diagnoses of autism spectrum disorder"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1164-8553","authenticated-orcid":false,"given":"Ozge","family":"Oztan","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Garner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305;"},{"name":"Department of Comparative Medicine, Stanford University, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Constantino","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110;"},{"name":"Department of Pediatrics, Washington University in St. Louis, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6836-6338","authenticated-orcid":false,"given":"Karen J.","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"CD009260","article-title":"Early intensive behavioral intervention (EIBI) for young children with autism spectrum disorders (ASD)","volume":"10","author":"Reichow B.","year":"2012","unstructured":"B. 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