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However, the wide structural diversity of carbohydrates hampers the characterization of specific glycan determinants. Here, we characterized the receptor recognition of type IV pili (Tfp), a key adhesive factor present in numerous bacterial pathogens, using\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    as a model organism. We found that meningococcal Tfp specifically recognize a triantennary sialylated poly-\n                    <jats:italic>N<\/jats:italic>\n                    -acetyllactosamine\u2013containing\n                    <jats:italic>N<\/jats:italic>\n                    -glycan exposed on the human receptor CD147\/Basigin, while fucosylated derivatives of this\n                    <jats:italic>N<\/jats:italic>\n                    -glycan impaired bacterial adhesion. Corroborating the inhibitory role of fucosylation on receptor recognition, adhesion of the meningococcus on nonhuman cells expressing human CD147 required prior defucosylation. These findings reveal the molecular basis of the selective receptor recognition by meningococcal Tfp and thereby, identify a potential antibacterial target.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1919567117","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T17:59:45Z","timestamp":1579629585000},"page":"2606-2612","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":24,"title":["Receptor recognition by meningococcal type IV pili relies on a specific complex\n                    <i>N<\/i>\n                    -glycan"],"prefix":"10.1073","volume":"117","author":[{"given":"Loic","family":"Le Guennec","sequence":"first","affiliation":[{"name":"INSERM, U1016, Institut Cochin, 75014 Paris, France;"},{"name":"UMR8104, CNRS, 75014 Paris, France;"},{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Descartes, 75006 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00e9","family":"Virion","sequence":"additional","affiliation":[{"name":"INSERM, Unit\u00e9 U1151, Institut Necker Enfants Malades, 75015 Paris, France;"},{"name":"UMR8253, CNRS, 75015 Paris, France;"},{"name":"Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Descartes, 75006 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haniaa","family":"Bouzinba-S\u00e9gard","sequence":"additional","affiliation":[{"name":"INSERM, U1016, Institut Cochin, 75014 Paris, France;"},{"name":"UMR8104, CNRS, 75014 Paris, France;"},{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Descartes, 75006 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Robbe-Masselot","sequence":"additional","affiliation":[{"name":"CNRS, UMR8576-UGSF Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, Universit\u00e9 Lille, F59000 Lille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"L\u00e9onard","sequence":"additional","affiliation":[{"name":"CNRS, UMR8576-UGSF Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, Universit\u00e9 Lille, F59000 Lille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Nassif","sequence":"additional","affiliation":[{"name":"INSERM, Unit\u00e9 U1151, Institut Necker Enfants Malades, 75015 Paris, France;"},{"name":"UMR8253, CNRS, 75015 Paris, France;"},{"name":"Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Descartes, 75006 Paris, France;"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants Malades, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2852-4765","authenticated-orcid":false,"given":"Sandrine","family":"Bourdoulous","sequence":"additional","affiliation":[{"name":"INSERM, U1016, Institut Cochin, 75014 Paris, France;"},{"name":"UMR8104, CNRS, 75014 Paris, France;"},{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Descartes, 75006 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-9685","authenticated-orcid":false,"given":"Mathieu","family":"Coureuil","sequence":"additional","affiliation":[{"name":"INSERM, Unit\u00e9 U1151, Institut Necker Enfants Malades, 75015 Paris, France;"},{"name":"UMR8253, CNRS, 75015 Paris, France;"},{"name":"Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Descartes, 75006 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"e00584-16","DOI":"10.1128\/mBio.00584-16","article-title":"Lectin-glycan interaction network-based identification of host receptors of microbial pathogenic adhesins","volume":"7","author":"Ielasi F. 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