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Our results, using New World arenavirus-infected mice heterozygous for the \u03b11S chain of the VGCC, human cells heterozygous for a mutation of this chain, and drugs that target this receptor, highlight the influence of genetic background on the outcome of infection and zoonoses. These findings also confirm the use of VGCCs as potential therapeutic targets and pave the way for understanding the relationship between genetics, susceptibility to infection, and antiviral drug efficacy.<\/jats:p>","DOI":"10.1073\/pnas.1920551117","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T20:30:26Z","timestamp":1595881826000},"page":"19497-19506","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":15,"title":["CACNA1S haploinsufficiency confers resistance to New World arenavirus infection"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6432-1880","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Sarute","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3094-3769","authenticated-orcid":false,"given":"Susan R.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-101416-042001"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007415"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0012-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-015-2418-y"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.08.027"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02392-07"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/v4010083"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05539"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000358"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01625-09"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05304-11"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/v4102317"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006827"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003947"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2010.05.007"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOBB.0000008026.37790.5a"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00375"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00243"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124263"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00039.2011"},{"key":"e_1_3_3_21_2","first-page":"37","article-title":"Genetic neurological channelopathies: Molecular genetics and clinical phenotypes","volume":"87","author":"Spillane J.","year":"2016","unstructured":"J. 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