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However, the burden of frequent intravitreal injections reduces patient compliance such that the impact in the \u201creal world\u201d is less than in clinical trials. Thus, there is a need to discover VEGF inhibitors than can be administered less frequently. We hypothesized that the ability to bind heparan-sulfate proteoglycans may be a strategy to promote intraocular retention and increase half-life. We designed a series of VEGF receptor 1 variants and identified some with strong heparin-binding characteristics that are more effective and durable in action in animal models of intraocular neovascularization than a standard of care like aflibercept. 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