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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,3,24]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Coxiella burnetii<\/jats:italic>\n                    is a unique bacterial pathogen that replicates to high numbers in a lysosome-like intracellular niche. This study identified host proteins that contribute to the pathogen\u2019s capacity to establish this niche and activate the Dot\/Icm secretion system required for intracellular replication. Many host proteins were found to contribute to the establishment of\n                    <jats:italic>C. burnetii<\/jats:italic>\n                    virulence by aiding trafficking of the pathogen to the lysosome and creating the degradative lysosome environment. Pathogenic bacteria are able to sense and adapt to their environment by altering their gene expression profile. Here we demonstrated that\n                    <jats:italic>C. burnetii<\/jats:italic>\n                    detects specific amino acids present in the lysosome using a two-component system that up-regulates expression of genes required for Dot\/Icm activity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1921344117","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T20:26:14Z","timestamp":1583785574000},"page":"6801-6810","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":56,"title":["Lysosomal degradation products induce\n                    <i>Coxiella burnetii<\/i>\n                    virulence"],"prefix":"10.1073","volume":"117","author":[{"given":"Patrice","family":"Newton","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawna C. 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L\u00fchrmann, H. J. Newton, M. Bonazzi, Beginning to understand the role of the type IV secretion system effector proteins in Coxiella burnetii pathogenesis. Curr. Top. Microbiol. Immunol. 413, 243\u2013268 (2017).","journal-title":"Curr. Top. Microbiol. 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