{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:18:01Z","timestamp":1792466281174,"version":"4.5.0"},"reference-count":46,"publisher":"National Academy of Sciences","issue":"12","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,3,24]]},"abstract":"<jats:p>\n                    A comprehensive understanding of the development and evolution of human B cell responses induced by pathogen exposure will facilitate the design of next-generation vaccines. Here, we utilized a high-throughput single B cell cloning technology to longitudinally track the human B cell response to the yellow fever virus 17D (YFV-17D) vaccine. The early memory B cell (MBC) response was mediated by both classical immunoglobulin M (IgM) (IgM\n                    <jats:sup>+<\/jats:sup>\n                    CD27\n                    <jats:sup>+<\/jats:sup>\n                    ) and switched immunoglobulin (swIg\n                    <jats:sup>+<\/jats:sup>\n                    ) MBC populations; however, classical IgM MBCs waned rapidly, whereas swIg\n                    <jats:sup>+<\/jats:sup>\n                    and atypical IgM\n                    <jats:sup>+<\/jats:sup>\n                    and IgD\n                    <jats:sup>+<\/jats:sup>\n                    MBCs were stable over time. Affinity maturation continued for 6 to 9 mo following vaccination, providing evidence for the persistence of germinal center activity long after the period of active viral replication in peripheral blood. Finally, a substantial fraction of the neutralizing antibody response was mediated by public clones that recognize a fusion loop-proximal antigenic site within domain II of the viral envelope glycoprotein. Overall, our findings provide a framework for understanding the dynamics and complexity of human B cell responses elicited by infection and vaccination.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1921388117","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T20:25:29Z","timestamp":1583785529000},"page":"6675-6685","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":103,"title":["Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine"],"prefix":"10.1073","volume":"117","author":[{"given":"Anna Z.","family":"Wec","sequence":"first","affiliation":[{"name":"Adimab, LLC, Lebanon, NH 03766;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Haslwanter","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmina N.","family":"Abdiche","sequence":"additional","affiliation":[{"name":"Carterra Inc., Salt Lake City, UT 84103;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Shehata","sequence":"additional","affiliation":[{"name":"Adimab, LLC, Lebanon, NH 03766;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Pedre\u00f1o-Lopez","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Miami, Miami, FL 33146;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal L.","family":"Moyer","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical, Inc., San Diego, CA 92121;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Bornholdt","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical, Inc., San Diego, CA 92121;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asparouh","family":"Lilov","sequence":"additional","affiliation":[{"name":"Adimab, LLC, Lebanon, NH 03766;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen H.","family":"Nett","sequence":"additional","affiliation":[{"name":"Adimab, LLC, Lebanon, NH 03766;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit K.","family":"Jangra","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brown","sequence":"additional","affiliation":[{"name":"Adimab, LLC, Lebanon, NH 03766;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Miami, Miami, FL 33146;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clas","family":"Ahlm","sequence":"additional","affiliation":[{"name":"Division of Infection &amp; Immunology, Department of Clinical Microbiology, Ume\u00e5 University, 90187 Ume\u00e5, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias N.","family":"Forsell","sequence":"additional","affiliation":[{"name":"Division of Infection &amp; Immunology, Department of Clinical Microbiology, Ume\u00e5 University, 90187 Ume\u00e5, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9953-7988","authenticated-orcid":false,"given":"F\u00e9lix A.","family":"Rey","sequence":"additional","affiliation":[{"name":"Structural Virology Unit, CNRS UMR 3569, Virology Department, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Barba-Spaeth","sequence":"additional","affiliation":[{"name":"Structural Virology Unit, CNRS UMR 3569, Virology Department, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0232-7077","authenticated-orcid":false,"given":"Kartik","family":"Chandran","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Walker","sequence":"additional","affiliation":[{"name":"Adimab, LLC, Lebanon, NH 03766;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.immuni.2016.09.001","article-title":"Germinal center B cell dynamics","volume":"45","author":"Mesin L.","year":"2016","unstructured":"L. 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