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Thus, TrxR2 represents a central control point of peroxynitrite levels by providing reducing equivalents to mitochondrial peroxiredoxins that, in turn, catalytically reduce peroxynitrite to nitrite. The data additionally support pharmacological approaches for mitochondrial peroxynitrite detoxification under conditions of vascular oxidative stress.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1921828118","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T00:52:06Z","timestamp":1613177526000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":61,"title":["The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9824-4323","authenticated-orcid":false,"given":"Petra","family":"Kameritsch","sequence":"first","affiliation":[{"name":"Walter Brendel Centre of Experimental Medicine, Biomedical Center Munich, Ludwig-Maximilians-University, 82152 Planegg, 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