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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,9,8]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    \u03b3\u03b4 T cells reside in barrier tissues and provide immune protection against infection and cancer. Their antitumor potential has led to recent advances in the development of \u03b3\u03b4 T cell immunotherapy. However, our understanding of the basic biology of these cells, including which molecules and pathways control their maintenance within barrier tissues, remains poor. We demonstrate that \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    integrin adhesion molecules play a major role in regulating \u03b3\u03b4 T cell subset numbers during homeostasis: the loss of \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    integrin expression results in a striking increase in IL-17\u2013producing \u03b3\u03b4 T cells in the lungs and uterus due to enhanced survival. These findings illustrate a mechanism of \u03b3\u03b4 T cell regulation that may have significant implications for immunotherapy development.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1921930117","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T20:05:35Z","timestamp":1598472335000},"page":"22367-22377","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":13,"title":["\u03b22 Integrins differentially regulate \u03b3\u03b4 T cell subset thymic development and peripheral maintenance"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-7724","authenticated-orcid":false,"given":"Claire L.","family":"McIntyre","sequence":"first","affiliation":[{"name":"Institute of Infection, Immunity &amp; Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-8105","authenticated-orcid":false,"given":"Leticia","family":"Monin","sequence":"additional","affiliation":[{"name":"Immunosurveillance Laboratory, The Francis Crick Institute, NW1 1AT London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0054-1782","authenticated-orcid":false,"given":"Jesse C.","family":"Rop","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity &amp; 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