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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,5,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>For the past 50 y, antibiotics have cured common bacterial infections quickly and effectively. Many strains of bacteria, however, are gaining resistance to common antibiotics. The solution to this problem includes a more judicious use of antibiotic therapies, directed by rapid point-of-care antibiotic susceptibility tests. The focus here is a simple all-electrical sensing approach implemented in a microfluidic device that measures the growth of a tiny bacteria sample in antibiotics. This approach has the potential to rapidly provide antibiotic susceptibility of bacteria along with minimum inhibitory concentrations and inform of the mechanisms of action of antibiotics\u2014all without resorting to high-resolution microscopy.<\/jats:p>","DOI":"10.1073\/pnas.1922172117","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T19:57:49Z","timestamp":1588190269000},"page":"10639-10644","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":85,"title":["All-electrical monitoring of bacterial antibiotic susceptibility in a microfluidic device"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-574X","authenticated-orcid":false,"given":"Yichao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Division of Materials Science and Engineering, Boston University, Boston, MA 02215;"},{"name":"Photonics Center, Boston University, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6766-3576","authenticated-orcid":false,"given":"Kalpana","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Infectious Diseases, Veterans Affairs Boston Healthcare System, Boston, MA 02132;"},{"name":"Department of Medicine, Boston University School of Medicine, Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5019-5489","authenticated-orcid":false,"given":"Kamil L.","family":"Ekinci","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Division of Materials Science and Engineering, Boston University, Boston, MA 02215;"},{"name":"Photonics Center, Boston University, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17042"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3380"},{"key":"e_1_3_3_3_2","first-page":"341","article-title":"A method for antibiotic susceptibility testing: Applicable and accurate","volume":"5","author":"Ataee R. 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