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Here, we show that polyamines transported by ATP13A2 provide cellular protection by lowering reactive oxygen species (ROS), which may relate to the antioxidant properties of polyamines. Consequently, dysfunctional ATP13A2 sensitizes cells to oxidative stress, which impairs mitochondria, and induces toxicity and cell death. ATP13A2-mediated polyamine transport represents a conserved pathway that protects against mitochondrial oxidative stress. The combined protective impact of ATP13A2 on lysosomal health and mitochondrial oxidative stress may explain why ATP13A2 exerts potent neuroprotective effects.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1922342117","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T21:17:14Z","timestamp":1606166234000},"page":"31198-31207","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":116,"title":["ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2601-510X","authenticated-orcid":false,"given":"Stephanie","family":"Vrijsen","sequence":"first","affiliation":[{"name":"Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven (KU Leuven), 3000 Leuven, 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