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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,12,8]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Marburg virus (MARV) is a member of the Filoviridae family that causes severe hemorrhagic fevers with high fatality rates in humans. Despite the major efforts made to develop an effective vaccine after the most recent filovirus outbreak, still no Food and Drug Administration-licensed MARV disease vaccines exist. A good vaccine should be capable of eliciting neutralizing antibodies in MARV-na\u00efve humans. This requires preexistence of antibodies with some affinity to the antigen. Here we used a large-scale computational antibody structure prediction approach to identify whether the epitope of the human anti-MARV monoclonal antibody MR78 can be recognized by antibodies from MARV-na\u00efve humans and thus whether it is a promising candidate for vaccine design.<\/jats:p>","DOI":"10.1073\/pnas.1922654117","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T20:44:44Z","timestamp":1606164284000},"page":"31142-31148","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":20,"title":["Discovery of Marburg virus neutralizing antibodies from virus-na\u00efve human antibody repertoires using large-scale structural predictions"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2164-5698","authenticated-orcid":false,"given":"Nina G.","family":"Bozhanova","sequence":"first","affiliation":[{"name":"Department of Chemistry, Vanderbilt University, Nashville, TN 37235;"},{"name":"Center for Structural Biology, Vanderbilt University, Nashville, TN 37235;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandeep K.","family":"Sangha","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Vanderbilt University, Nashville, TN 37235;"},{"name":"Center for Structural Biology, Vanderbilt University, Nashville, TN 37235;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2380-2861","authenticated-orcid":false,"given":"Alexander M.","family":"Sevy","sequence":"additional","affiliation":[{"name":"Center for Structural Biology, Vanderbilt University, Nashville, TN 37235;"},{"name":"Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlo","family":"Gilchuk","sequence":"additional","affiliation":[{"name":"Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3373-5594","authenticated-orcid":false,"given":"Kai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555;"},{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel S.","family":"Nargi","sequence":"additional","affiliation":[{"name":"Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph X.","family":"Reidy","sequence":"additional","affiliation":[{"name":"Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Trivette","sequence":"additional","affiliation":[{"name":"Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Carnahan","sequence":"additional","affiliation":[{"name":"Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232;"},{"name":"Department of Pediatrics, Vanderbilt University Medical Center, Nashville TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0342-4824","authenticated-orcid":false,"given":"Alexander","family":"Bukreyev","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555;"},{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550;"},{"name":"Department of Microbiology &amp; 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