{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:45:51Z","timestamp":1791942351934,"version":"4.3.4"},"reference-count":50,"publisher":"National Academy of Sciences","issue":"20","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>\n                    The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent,\n                    <jats:italic>Brucella<\/jats:italic>\n                    <jats:italic>suis<\/jats:italic>\n                    , was determined. Comparison of\n                    <jats:italic>B.<\/jats:italic>\n                    <jats:italic>suis<\/jats:italic>\n                    with\n                    <jats:italic>Brucella<\/jats:italic>\n                    <jats:italic>melitensis<\/jats:italic>\n                    has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the\n                    <jats:italic>B.<\/jats:italic>\n                    <jats:italic>suis<\/jats:italic>\n                    genome reveals transport and metabolic capabilities akin to soil\/plant-associated bacteria. Extensive gene synteny between\n                    <jats:italic>B.<\/jats:italic>\n                    <jats:italic>suis<\/jats:italic>\n                    chromosome 1 and the genome of the plant symbiont\n                    <jats:italic>Mesorhizobium<\/jats:italic>\n                    <jats:italic>loti<\/jats:italic>\n                    emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.\n                  <\/jats:p>","DOI":"10.1073\/pnas.192319099","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T12:58:07Z","timestamp":1033477087000},"page":"13148-13153","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":385,"title":["The\n                    <i>Brucella<\/i>\n                    <i>suis<\/i>\n                    genome reveals fundamental similarities between animal and plant pathogens and symbionts"],"prefix":"10.1073","volume":"99","author":[{"given":"Ian T.","family":"Paulsen","sequence":"first","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Nelson","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Eisen","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Heidelberg","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Read","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Dodson","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lowell","family":"Umayam","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Brinkac","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen J.","family":"Beanan","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean C.","family":"Daugherty","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Deboy","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Scott","family":"Durkin","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Kolonay","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramana","family":"Madupu","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Nelson","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bola","family":"Ayodeji","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Kraul","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Shetty","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Malek","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Van Aken","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Riedmuller","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herve","family":"Tettelin","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Gill","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"White","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Salzberg","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Hoover","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luther E.","family":"Lindler","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley M.","family":"Halling","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Boyle","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M.","family":"Fraser","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910; National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010-0070; Center for Molecular Medicine and Infectious Diseases, Virginia\u2013Maryland Regional College of Veterinary Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2002,9,23]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/clinids\/21.2.283","volume":"21","author":"Young E J","year":"1995","unstructured":"E J Young Clin Infect Dis 21, 283\u2013289 (1995).","journal-title":"Clin Infect Dis"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1749-6632.1999.tb08051.x","volume":"894","author":"Franz D R","year":"1999","unstructured":"D R Franz Ann NY Acad Sci 894, 100\u2013104 (1999).","journal-title":"Ann NY Acad Sci"},{"key":"e_1_3_4_3_2","volume-title":"The Biology of Doom: The History of America's Secret Germ Warfare Project","author":"Regis E","year":"1999","unstructured":"E Regis The Biology of Doom: The History of America's Secret Germ Warfare Project (Henry Holt and Associates, New York, 1999)."},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3201\/eid0504.990411","volume":"5","author":"Kortepeter M G","year":"1999","unstructured":"M G Kortepeter, G W Parker Emerg Infect Dis 5, 523\u2013527 (1999).","journal-title":"Emerg Infect Dis"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1749-6632.1999.tb08037.x","volume":"894","author":"Horn F P","year":"1999","unstructured":"F P Horn, R G Breeze Ann NY Acad Sci 894, 9\u201317 (1999).","journal-title":"Ann NY Acad Sci"},{"key":"e_1_3_4_6_2","first-page":"147","volume":"13","author":"Nicoletti P","year":"1990","unstructured":"P Nicoletti Adv Biotechnol Processes 13, 147\u2013168 (1990).","journal-title":"Adv Biotechnol Processes"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1128\/IAI.68.7.4255-4263.2000","volume":"68","author":"Arenas G N","year":"2000","unstructured":"G N Arenas, A S Staskevich, A Aballay, L S Mayorga Infect Immun 68, 4255\u20134263 (2000).","journal-title":"Infect Immun"},{"key":"e_1_3_4_8_2","first-page":"363","volume":"60","author":"Baldwin C L","year":"1994","unstructured":"C L Baldwin, A J Winter Immunol Ser 60, 363\u2013380 (1994).","journal-title":"Immunol Ser"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1128\/IAI.69.1.486-493.2001","volume":"69","author":"Naroeni A","year":"2001","unstructured":"A Naroeni, N Jouy, S Ouahrani-Bettache, J P Liautard, F Porte Infect Immun 69, 486\u2013493 (2001).","journal-title":"Infect Immun"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/030098588602300302","volume":"23","author":"Anderson T D","year":"1986","unstructured":"T D Anderson, N F Cheville, V P Meador Vet Pathol 23, 227\u2013239 (1986).","journal-title":"Vet Pathol"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1128\/IAI.66.12.5711-5724.1998","volume":"66","author":"Pizarro-Cerda J","year":"1998","unstructured":"J Pizarro-Cerda, S Meresse, R G Parton, G van der Goot, A Sola-Landa, I Lopez-Goni, E Moreno, J P Gorvel Infect Immun 66, 5711\u20135724 (1998).","journal-title":"Infect Immun"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/nar\/26.2.544","volume":"26","author":"Salzberg S L","year":"1998","unstructured":"S L Salzberg, A L Delcher, S Kasif, O White Nucleic Acids Res 26, 544\u2013548 (1998).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1093\/nar\/27.23.4636","volume":"27","author":"Delcher A L","year":"1999","unstructured":"A L Delcher, D Harmon, S Kasif, O White, S L Salzberg Nucleic Acids Res 27, 4636\u20134641 (1999).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1126\/science.7542800","volume":"269","author":"Fleischmann R D","year":"1995","unstructured":"R D Fleischmann, M D Adams, O White, R A Clayton, E F Kirkness, A R Kerlavage, C J Bult, J F Tomb, B A Dougherty, J M Merrick, et al. Science 269, 496\u2013512 (1995).","journal-title":"Science"},{"key":"e_1_3_4_15_2","first-page":"685","volume":"10","author":"Claros M G","year":"1994","unstructured":"M G Claros, G von Heijne Comput Appl Biosci 10, 685\u2013686 (1994).","journal-title":"Comput Appl Biosci"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/protein\/10.1.1","volume":"10","author":"Nielsen H","year":"1997","unstructured":"H Nielsen, J Engelbrecht, S Brunak, G von Heijne Protein Eng 10, 1\u20136 (1997).","journal-title":"Protein Eng"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/nar\/28.1.263","volume":"28","author":"Bateman A","year":"2000","unstructured":"A Bateman, E Birney, R Durbin, S R Eddy, K L Howe, E L Sonnhammer Nucleic Acids Res 28, 263\u2013266 (2000).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/nar\/29.1.41","volume":"29","author":"Haft D H","year":"2001","unstructured":"D H Haft, B J Loftus, D L Richardson, F Yang, J A Eisen, I T Paulsen, O White Nucleic Acids Res 29, 41\u201343 (2001).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1073\/pnas.061029298","volume":"98","author":"Nierman W C","year":"2001","unstructured":"W C Nierman, T V Feldblyum, M T Laub, I T Paulsen, K E Nelson, J Eisen, J F Heidelberg, M R Alley, N Ohta, J R Maddock, et al. Proc Natl Acad Sci USA 98, 4136\u20134141 (2001).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_20_2","first-page":"185","volume":"132","author":"Pearson W R","year":"2000","unstructured":"W R Pearson Methods Mol Biol 132, 185\u2013219 (2000).","journal-title":"Methods Mol Biol"},{"key":"e_1_3_4_21_2","first-page":"27","volume":"31","author":"Morgan W J","year":"1976","unstructured":"W J Morgan, M J Corbel Dev Biol Stand 31, 27\u201337 (1976).","journal-title":"Dev Biol Stand"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1126\/science.1061217","volume":"293","author":"Tettelin H","year":"2001","unstructured":"H Tettelin, K E Nelson, I T Paulsen, J A Eisen, T D Read, S Peterson, J Heidelberg, R T DeBoy, D H Haft, R J Dodson, et al. Science 293, 498\u2013506 (2001).","journal-title":"Science"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1365-2958.1998.00661.x","volume":"27","author":"Jumas-Bilak E","year":"1998","unstructured":"E Jumas-Bilak, S Michaux-Charachon, G Bourg, D O'Callaghan, M Ramuz Mol Microbiol 27, 99\u2013106 (1998).","journal-title":"Mol Microbiol"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/oxfordjournals.molbev.a025626","volume":"13","author":"Lobry J R","year":"1996","unstructured":"J R Lobry Mol Biol Evol 13, 660\u2013665 (1996).","journal-title":"Mol Biol Evol"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/35020000","volume":"406","author":"Heidelberg J F","year":"2000","unstructured":"J F Heidelberg, J A Eisen, W C Nelson, R A Clayton, M L Gwinn, R J Dodson, D H Haft, E K Hickey, J D Peterson, L Umayam, et al. Nature (London) 406, 477\u2013483 (2000).","journal-title":"Nature (London)"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1073\/pnas.221575398","volume":"99","author":"DelVecchio V G","year":"2002","unstructured":"V G DelVecchio, V Kapatral, R J Redkar, G Patra, C Mujer, T Los, N Ivanova, I Anderson, A Bhattacharyya, A Lykidis, et al. Proc Natl Acad Sci USA 99, 443\u2013448 (2002).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1128\/JCM.39.1.235-240.2001","volume":"39","author":"Gandara B","year":"2001","unstructured":"B Gandara, A L Merino, M A Rogel, E Martinez-Romero J Clin Microbiol 39, 235\u2013240 (2001).","journal-title":"J Clin Microbiol"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1099\/00207713-35-3-292","volume":"35","author":"Verger J-M","year":"1985","unstructured":"J-M Verger, F Grimont, P A Grimont, M Grayon Int J Syst Bacteriol 35, 292\u2013295 (1985).","journal-title":"Int J Syst Bacteriol"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/35054089","volume":"409","author":"Perna N T","year":"2001","unstructured":"N T Perna, G Plunkett, V Burland, B Mau, J D Glasner, D J Rose, G F Mayhew, P S Evans, J Gregor, H A Kirkpatrick, et al. Nature (London) 409, 529\u2013533 (2001).","journal-title":"Nature (London)"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3109\/10408419009105726","volume":"17","author":"Smith L D","year":"1990","unstructured":"L D Smith, T A Ficht Crit Rev Microbiol 17, 209\u2013230 (1990).","journal-title":"Crit Rev Microbiol"},{"key":"e_1_3_4_31_2","volume-title":"Hagan and Bruner's Microbiology and Infectious Diseases of Domestic Animals","author":"Timoney J F","year":"1988","unstructured":"J F Timoney Hagan and Bruner's Microbiology and Infectious Diseases of Domestic Animals (Comstock Publishing Associates, Ithaca, NY, 1988)."},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1128\/jb.172.7.3569-3576.1990","volume":"172","author":"Moreno E","year":"1990","unstructured":"E Moreno, E Stackebrandt, M Dorsch, J Wolters, M Busch, H Mayer J Bacteriol 172, 3569\u20133576 (1990).","journal-title":"J Bacteriol"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/dnares\/7.6.331","volume":"7","author":"Kaneko T","year":"2000","unstructured":"T Kaneko, Y Nakamura, S Sato, E Asamizu, T Kato, S Sasamoto, A Watanabe, K Idesawa, A Ishikawa, K Kawashima, et al. DNA Res 7, 331\u2013338 (2000).","journal-title":"DNA Res"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.1060966","volume":"293","author":"Galibert F","year":"2001","unstructured":"F Galibert, T M Finan, S R Long, A Puhler, P Abola, F Ampe, F Barloy-Hubler, M J Barnett, A Becker, P Boistard, et al. Science 293, 668\u2013672 (2001).","journal-title":"Science"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","unstructured":"Eisen J. A. Heidelberg J. F. White O. & Salzberg S. L. (2000) Genome Biol. 1 research0011.1\u20130011.9.","DOI":"10.1186\/gb-2000-1-6-research0011"},{"key":"e_1_3_4_36_2","first-page":"504","volume":"55","author":"Cotton W E","year":"1919","unstructured":"W E Cotton J Am Vet Med Assoc 55, 504\u2013528 (1919).","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_3_4_37_2","volume-title":"A Guide to the Diagnosis, Treatment and Prevention of Human Brucellosis","author":"Elberg S S","year":"1981","unstructured":"S S Elberg A Guide to the Diagnosis, Treatment and Prevention of Human Brucellosis (World Health Organization, Geneva, 1981)."},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/jmbi.2000.3961","volume":"301","author":"Paulsen I T","year":"2000","unstructured":"I T Paulsen, L Nguyen, M K Sliwinski, R Rabus, M H Saier J Mol Biol 301, 75\u2013100 (2000).","journal-title":"J Mol Biol"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1126\/science.1066804","volume":"294","author":"Wood D W","year":"2001","unstructured":"D W Wood, J C Setubal, R Kaul, D E Monks, J P Kitajima, V K Okura, Y Zhou, L Chen, G E Wood, N F Almeida, et al. Science 294, 2317\u20132323 (2001).","journal-title":"Science"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1046\/j.1365-2958.2002.02805.x","volume":"43","author":"Kingsley R A","year":"2002","unstructured":"R A Kingsley, R L Santos, A M Keestra, L G Adams, A J Baumler Mol Microbiol 43, 895\u2013905 (2002).","journal-title":"Mol Microbiol"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1128\/iai.57.5.1506-1511.1989","volume":"57","author":"Benz I","year":"1989","unstructured":"I Benz, M A Schmidt Infect Immun 57, 1506\u20131511 (1989).","journal-title":"Infect Immun"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF02889960","volume":"52","author":"Gay B","year":"1986","unstructured":"B Gay, H Mauss, S Sanchez-Teff Virchows Arch B Cell Pathol Incl Mol Pathol 52, 169\u2013176 (1986).","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"6750","DOI":"10.1128\/IAI.68.12.6750-6757.2000","volume":"68","author":"Carroll J A","year":"2000","unstructured":"J A Carroll, S A Coleman, L S Smitherman, M F Minnick Infect Immun 68, 6750\u20136757 (2000).","journal-title":"Infect Immun"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1128\/IAI.69.7.4373-4381.2001","volume":"69","author":"Coleman S A","year":"2001","unstructured":"S A Coleman, M F Minnick Infect Immun 69, 4373\u20134381 (2001).","journal-title":"Infect Immun"},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1128\/iai.63.4.1552-1562.1995","volume":"63","author":"Mitchell S J","year":"1995","unstructured":"S J Mitchell, M F Minnick Infect Immun 63, 1552\u20131562 (1995).","journal-title":"Infect Immun"},{"key":"e_1_3_4_46_2","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1128\/IAI.66.11.5485-5493.1998","volume":"66","author":"Godfroid F","year":"1998","unstructured":"F Godfroid, B Taminiau, I Danese, P Denoel, A Tibor, V Weynants, A Cloeckaert, J Godfroid, J J Letesson Infect Immun 66, 5485\u20135493 (1998).","journal-title":"Infect Immun"},{"key":"e_1_3_4_47_2","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1128\/IAI.68.3.1297-1303.2000","volume":"68","author":"Foulongne V","year":"2000","unstructured":"V Foulongne, G Bourg, C Cazevieille, S Michaux-Charachon, D O'Callaghan Infect Immun 68, 1297\u20131303 (2000).","journal-title":"Infect Immun"},{"key":"e_1_3_4_48_2","first-page":"262","volume":"13","author":"de Koning-Ward T F","year":"1995","unstructured":"T F de Koning-Ward, A C Ward, E L Hartland, R M Robins-Browne Contrib Microbiol Immunol 13, 262\u2013263 (1995).","journal-title":"Contrib Microbiol Immunol"},{"key":"e_1_3_4_49_2","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1128\/jb.177.19.5644-5652.1995","volume":"177","author":"Clemens D L","year":"1995","unstructured":"D L Clemens, B Y Lee, M A Horwitz J Bacteriol 177, 5644\u20135652 (1995).","journal-title":"J Bacteriol"},{"key":"e_1_3_4_50_2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1128\/JB.183.2.426-434.2001","volume":"183","author":"Jubier-Maurin V","year":"2001","unstructured":"V Jubier-Maurin, A Rodrigue, S Ouahrani-Bettache, M Layssac, M A Mandrand-Berthelot, S Kohler, J P Liautard J Bacteriol 183, 426\u2013434 (2001).","journal-title":"J Bacteriol"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.192319099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T01:46:35Z","timestamp":1654566395000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.192319099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9,23]]},"references-count":50,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1073\/pnas.192319099"],"URL":"https:\/\/doi.org\/10.1073\/pnas.192319099","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1009812.135460","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9,23]]},"assertion":[{"value":"2002-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-09-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}