{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:48:49Z","timestamp":1790711329241,"version":"4.1.0"},"reference-count":41,"publisher":"National Academy of Sciences","issue":"27","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["093445"],"award-info":[{"award-number":["093445"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["205041"],"award-info":[{"award-number":["205041"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000615","name":"Fight for Sight UK","doi-asserted-by":"publisher","award":["1936UCL"],"award-info":[{"award-number":["1936UCL"]}],"id":[{"id":"10.13039\/501100000615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"RCUK | Medical Research Council","doi-asserted-by":"publisher","award":["G108523"],"award-info":[{"award-number":["G108523"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"RCUK | Medical Research Council","doi-asserted-by":"publisher","award":["G0700949"],"award-info":[{"award-number":["G0700949"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,7,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Mitochondria play an essential role in the homeostasis of the highly energy-demanding photoreceptors and enable normal vision. We used 3D electron microscopy to show that the mitochondria in the photoreceptor inner segment are tethered to the plasma membrane in a highly specialized arrangement. This includes mitochondria running alongside each other in neighboring inner segments, with evidence of alignment of the cristae openings. The cristae structure was not greatly affected in photoreceptors of a heterozygous\n                    <jats:italic>Opa1<\/jats:italic>\n                    knockout mouse model, but the mitochondria were enlarged and had reduced alignment to neighboring inner-segment mitochondria. This leads us to propose that mitochondria are arranged to share metabolites and assist in maintaining homeostasis across the photoreceptor cell layer.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2000304117","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T20:36:40Z","timestamp":1592858200000},"page":"15684-15693","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":45,"title":["Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1"],"prefix":"10.1073","volume":"117","author":[{"given":"Ingrid P.","family":"Meschede","sequence":"first","affiliation":[{"name":"UCL Institute of Ophthalmology, University College London, EC1V 9EL London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9781-665X","authenticated-orcid":false,"given":"Nicholas C.","family":"Ovenden","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University College London, WC1E 6BT London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6404-4892","authenticated-orcid":false,"given":"Miguel C.","family":"Seabra","sequence":"additional","affiliation":[{"name":"UCL Institute of Ophthalmology, University College London, EC1V 9EL London, United Kingdom;"},{"name":"Centro de Estudos de Doen\u00e7as Cr\u00f3nicas, Universidade Nova de Lisboa, 1169-056 Lisbon, Portugal;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare E.","family":"Futter","sequence":"additional","affiliation":[{"name":"UCL Institute of Ophthalmology, University College London, EC1V 9EL London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7680-9135","authenticated-orcid":false,"given":"Marcela","family":"Votruba","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Sciences, Cardiff University, CF24 4HQ Cardiff, United Kingdom;"},{"name":"Cardiff Eye Unit, University Hospital Wales, CF14 4XW Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6429-654X","authenticated-orcid":false,"given":"Michael E.","family":"Cheetham","sequence":"additional","affiliation":[{"name":"UCL Institute of Ophthalmology, University College London, EC1V 9EL London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-720X","authenticated-orcid":false,"given":"Thomas","family":"Burgoyne","sequence":"additional","affiliation":[{"name":"UCL Institute of Ophthalmology, University College London, EC1V 9EL London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5614"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/EB.S9078"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.51998"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e328349419d"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28899"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2689-16.2017"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-2888-2_39"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.1.117"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2005.04.002"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2741\/krizaj"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523807070587"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm272"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/79944"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/79936"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.021"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.06.004"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.10.083"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.025"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.07.004"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-02-0096"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.03.001"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1517-09.2010"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201401126"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980824)398:2<257::AID-CNE7>3.0.CO;2-#"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2015.04.002"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17901"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013885"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18098-z"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.052"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7259"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep30610"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.379"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201107053"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.08.026"},{"key":"e_1_3_3_35_2","first-page":"434","article-title":"Comparative study of the fine structure of retinal M\u00fcller cells in various vertebrates","volume":"12","author":"Uga S.","year":"1973","unstructured":"S. Uga, G. K. Smelser, Comparative study of the fine structure of retinal M\u00fcller cells in various vertebrates. Invest. Ophthalmol. 12, 434\u2013448 (1973).","journal-title":"Invest. Ophthalmol."},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225597"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.565457"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604572113"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.10.034"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2018.07.006"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm079"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2000304117","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2000304117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T06:38:12Z","timestamp":1649831892000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2000304117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,22]]},"references-count":41,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2020,7,7]]}},"alternative-id":["10.1073\/pnas.2000304117"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2000304117","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/635094","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,22]]},"assertion":[{"value":"2020-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}