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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Many stroke patients exhibit long-term disability. Transplantation of stem cells has been proposed as a novel therapeutic strategy to promote recovery. However, little is known about whether these cells can form functionally integrated connections with neurons in the stroke-injured recipient\u2019s brain. Here we show extensive morphological and functional integration of axonal projections from intracortically transplanted human iPS cell\u2013derived cortical neurons in brains of rats with ischemic lesions in the cerebral cortex. We also demonstrate that neuronal activity in these grafts is involved in the regulation of the stroke-affected animals\u2019 motor behavior. Our findings raise the possibility that injured neural circuitry might be restored by stem cells also in humans affected by stroke, which would have major clinical implications.<\/jats:p>","DOI":"10.1073\/pnas.2000690117","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T20:25:58Z","timestamp":1586204758000},"page":"9094-9100","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":106,"title":["Activity in grafted human iPS cell\u2013derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior"],"prefix":"10.1073","volume":"117","author":[{"given":"Sara","family":"Palma-Tortosa","sequence":"first","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, Lund University, SE-22184 Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4812-4091","authenticated-orcid":false,"given":"Daniel","family":"Tornero","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, Lund University, SE-22184 Lund, Sweden;"},{"name":"Laboratory of Stem Cells and Regenerative Medicine, Institute of Neurosciences, University of Barcelona, ES-08036 Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita","family":"Gr\u00f8nning Hansen","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, Lund University, SE-22184 Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0083-1050","authenticated-orcid":false,"given":"Emanuela","family":"Monni","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, Lund University, SE-22184 Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazin","family":"Hajy","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, Lund University, SE-22184 Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sopiko","family":"Kartsivadze","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, Lund University, SE-22184 Lund, Sweden;"},{"name":"Department of Neurology, Iv. Javakhishvili Tbilisi State University, 0179 Tbilisi, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel","family":"Aktay","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, Lund University, SE-22184 Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-651X","authenticated-orcid":false,"given":"Oleg","family":"Tsupykov","sequence":"additional","affiliation":[{"name":"Department of Cytology, Bogomoletz Institute of Physiology, 01024 Kyiv, Ukraine;"},{"name":"Laboratory of Cell and Tissue Cultures, State Institute of Genetic and Regenerative Medicine, 04114 Kyiv, Ukraine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Parmar","sequence":"additional","affiliation":[{"name":"Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Lund Stem Cell Center, Lund University, SE-22184 Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Deisseroth","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Stanford University, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2187-6178","authenticated-orcid":false,"given":"Galyna","family":"Skibo","sequence":"additional","affiliation":[{"name":"Department of Cytology, Bogomoletz Institute of Physiology, 01024 Kyiv, Ukraine;"},{"name":"Laboratory of Cell and Tissue Cultures, State Institute of Genetic and Regenerative Medicine, 04114 Kyiv, Ukraine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"Lindvall","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, Lund University, SE-22184 Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2296-2449","authenticated-orcid":false,"given":"Zaal","family":"Kokaia","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, Lund University, SE-22184 Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1214"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.012995"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30046-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30513-X"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3163"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03877.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt278"},{"key":"e_1_3_3_8_2","first-page":"692","article-title":"Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli","volume":"140","author":"Tornero D.","year":"2017","unstructured":"D. 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