{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:28:32Z","timestamp":1787005712894,"version":"build-2736575974"},"reference-count":55,"publisher":"National Academy of Sciences","issue":"32","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000053","name":"HHS | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["RO1EY015304"],"award-info":[{"award-number":["RO1EY015304"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Maryland stem cell research foundation","award":["MD-15-1"],"award-info":[{"award-number":["MD-15-1"]}]},{"name":"Holt fund","award":["HF-1"],"award-info":[{"award-number":["HF-1"]}]},{"name":"Donner Fund","award":["DF-1"],"award-info":[{"award-number":["DF-1"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,8,11]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The optic nerve lamina region (ONLR) transitions between the eye and optic nerve (ON) and is the primary damage site in the age-related disease open angle glaucoma (OAG). The ONLR inhibits intraocular myelination and enables postnatal ON myelination of growing retinal ganglion cell axons. We show that the ONLR contains an adult neural progenitor cell (NPC) niche capable of generating all macroglial cell types for the anterior ON. Early ONLR-NPC loss causes regional dysfunction and myelination defects. Age-related depletion may help explain development of ON diseases such as OAG.<\/jats:p>","DOI":"10.1073\/pnas.2001858117","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T17:40:06Z","timestamp":1595958006000},"page":"19287-19298","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":21,"title":["The optic nerve lamina region is a neural progenitor cell niche"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7758-0136","authenticated-orcid":false,"given":"S. L.","family":"Bernstein","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201;"},{"name":"Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Division of Aging Biology, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8601-8268","authenticated-orcid":false,"given":"R. J.","family":"Fawcett","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Stern","sequence":"additional","affiliation":[{"name":"Age-Related Macular Degeneration Program, Neural Stem Cell Institute, Rensselaer, NY 12144"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Temple","sequence":"additional","affiliation":[{"name":"Age-Related Macular Degeneration Program, Neural Stem Cell Institute, Rensselaer, NY 12144"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Mehrabian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2016.141"},{"key":"e_1_3_3_2_2","first-page":"83","article-title":"A longitudinal radiographic study of the growth of the rat skull","volume":"127","author":"Hughes P. C. R.","year":"1978","unstructured":"P. C. R. Hughes, J. M. Tanner, J. P. G. Williams, A longitudinal radiographic study of the growth of the rat skull. J. Anat. 127, 83\u201391 (1978).","journal-title":"J. Anat."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10321"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1062303"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874364100802010094"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01735374"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013965108"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-07-02506.1998"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1989.92"},{"key":"e_1_3_3_10_2","first-page":"1702","article-title":"Microvasculature of the rat optic nerve head","volume":"40","author":"Morrison J. C.","year":"1999","unstructured":"J. C. Morrison, E. C. Johnson, W. O. Cepurna, R. H. Funk, Microvasculature of the rat optic nerve head. Invest. Ophthalmol. Vis. Sci. 40, 1702\u20131709 (1999).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_11_2","first-page":"2206","article-title":"Morphology of the murine optic nerve","volume":"43","author":"May C. A.","year":"2002","unstructured":"C. A. May, E. L\u00fctjen-Drecoll, Morphology of the murine optic nerve. Invest. Ophthalmol. Vis. Sci. 43, 2206\u20132212 (2002).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.07.026"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2539"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.07.025"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2004.10.010"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2013-0038"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22882"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/372263a0"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00086-6"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.09.009"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2011.0214"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-03-01049.1999"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022408"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11055-008-0025-z"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.055178"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(95)80002-6"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-7"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2013-0117"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2013-0191"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22539"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3812-07.2007"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1242\/bio.20122287"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-02314.2003"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/90795"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20571"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440140206"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23269"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0415-14.2014"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13307"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0467-6"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2323-12.2012"},{"key":"e_1_3_3_42_2","first-page":"78","article-title":"Cell culture of the human lamina cribrosa","volume":"29","author":"Hernandez M. R.","year":"1988","unstructured":"M. R. Hernandez, F. Igoe, A. H. Neufeld, Cell culture of the human lamina cribrosa. Invest. Ophthalmol. Vis. Sci. 29, 78\u201389 (1988).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.09.020"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20658"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.06.058"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22357"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.03.010"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000524"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00037-2"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23189"},{"key":"e_1_3_3_51_2","first-page":"131","article-title":"Postnatal development of the craniofacial skeleton in male C57BL\/6J mice","volume":"55","author":"Maga A. M.","year":"2016","unstructured":"A. M. Maga, Postnatal development of the craniofacial skeleton in male C57BL\/6J mice. J. Am. Assoc. Lab. Anim. Sci. 55, 131\u2013136 (2016).","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12261"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2010.112"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-5-51"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050021"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2001858117","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2001858117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T06:17:12Z","timestamp":1649830632000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2001858117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,28]]},"references-count":55,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2020,8,11]]}},"alternative-id":["10.1073\/pnas.2001858117"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2001858117","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,28]]},"assertion":[{"value":"2020-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}