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Here we uncover the impact of inflammasome activation and type 1 interferon on the expression of bacterial flagellin. Flagellin induces NLRC4 inflammasome-mediated pyroptosis causing clearance of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    . We show that inflammasome activation also produces lysophospholipids which increase flagellin expression by\n                    <jats:italic>Salmonella<\/jats:italic>\n                    early in infection. We further demonstrate that as infection progresses, type 1 IFN inhibits NLRC4 and lysophospholipid synthesis, resulting in down-regulation of flagellin expression, a phenotype that the pathogen switches to during establishment of in vivo infection. These findings unravel pathways for biphasic regulation of expression of flagellin, a key\n                    <jats:italic>Salmonella<\/jats:italic>\n                    effector.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2002747117","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T19:51:26Z","timestamp":1605124286000},"page":"29811-29822","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":17,"title":["Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of\n                    <i>Salmonella<\/i>\n                    flagellin inside macrophages"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0803-2416","authenticated-orcid":false,"given":"Ajay Suresh","family":"Akhade","sequence":"first","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA 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