{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:17:23Z","timestamp":1793193443773,"version":"4.5.0"},"reference-count":50,"publisher":"National Academy of Sciences","issue":"38","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81788101"],"award-info":[{"award-number":["81788101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,9,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    LncRNAs have been identified as regulating antiviral innate responses via different targets through various ways. Whether there is an abundant and highly conserved lncRNA in the nucleus which may regulate antiviral innate signaling through a new mechanism remains to be investigated. Here, we identify that viral infection-reduced expression of\n                    <jats:italic>Malat1<\/jats:italic>\n                    feedback promotes IRF3-initiated type I IFN production in the innate response against viral infection.\n                    <jats:italic>Malat1<\/jats:italic>\n                    binds to TDP43 and prevents its cleavage mediated by activated caspase-3. The cleaved TDP35 inhibits IRF3 degradation through promoting the degradation of pre-mRNA of Rbck1, an E3 ubiquitin ligase targeting IRF3. Aberrant\n                    <jats:italic>MALAT1<\/jats:italic>\n                    reduction and IRF3 activation are found in SLE patients, providing one mechanistic explanation for why SLE patients always have type I interferonopathies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2003932117","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T19:55:27Z","timestamp":1599681327000},"page":"23695-23706","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":137,"title":["LncRNA\n                    <i>Malat1<\/i>\n                    inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-1170","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, 100005 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6720-4732","authenticated-orcid":false,"given":"Ziqiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, 100005 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, 100005 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, 100005 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, 100005 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongfei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, 100005 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, 100005 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanwu","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 100021 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-2924","authenticated-orcid":false,"given":"Lianfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, 100021 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8775-1699","authenticated-orcid":false,"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 100730 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, 100005 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetao","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, 100005 Beijing, China;"},{"name":"National Key Laboratory of Medical Immunology and Institute of Immunology, Navy Medical University, 200433 Shanghai, China;"},{"name":"College of Life Science, Nankai University, 300071 Tianjin, 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Liu LncRNA Malat1 inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity. Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE134032. 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