{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:44:37Z","timestamp":1792791877737,"version":"4.5.0"},"reference-count":31,"publisher":"National Academy of Sciences","issue":"17","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Project of Ministry of Science and Technology of China","award":["2020YFC0841800"],"award-info":[{"award-number":["2020YFC0841800"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,4,28]]},"abstract":"<jats:p>\n                    Currently, there are no approved specific antiviral agents for novel coronavirus disease 2019 (COVID-19). In this study, 10 severe patients confirmed by real-time viral RNA test were enrolled prospectively. One dose of 200 mL of convalescent plasma (CP) derived from recently recovered donors with the neutralizing antibody titers above 1:640 was transfused to the patients as an addition to maximal supportive care and antiviral agents. The primary endpoint was the safety of CP transfusion. The second endpoints were the improvement of clinical symptoms and laboratory parameters within 3 d after CP transfusion. The median time from onset of illness to CP transfusion was 16.5 d. After CP transfusion, the level of neutralizing antibody increased rapidly up to 1:640 in five cases, while that of the other four cases maintained at a high level (1:640). The clinical symptoms were significantly improved along with increase of oxyhemoglobin saturation within 3 d. Several parameters tended to improve as compared to pretransfusion, including increased lymphocyte counts (0.65 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L vs. 0.76 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L) and decreased C-reactive protein (55.98 mg\/L vs. 18.13 mg\/L). Radiological examinations showed varying degrees of absorption of lung lesions within 7 d. The viral load was undetectable after transfusion in seven patients who had previous viremia. No severe adverse effects were observed. This study showed CP therapy was well tolerated and could potentially improve the clinical outcomes through neutralizing viremia in severe COVID-19 cases. The optimal dose and time point, as well as the clinical benefit of CP therapy, needs further investigation in larger well-controlled trials.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2004168117","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T20:26:06Z","timestamp":1586204766000},"page":"9490-9496","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1478,"title":["Effectiveness of convalescent plasma therapy in severe COVID-19 patients"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3401-7228","authenticated-orcid":false,"given":"Kai","family":"Duan","sequence":"first","affiliation":[{"name":"China National Biotec Group Company Limited, 100029 Beijing, China;"},{"name":"National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co. Ltd., 430207 Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bende","family":"Liu","sequence":"additional","affiliation":[{"name":"First People\u2019s Hospital of Jiangxia District, 430200 Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesheng","family":"Li","sequence":"additional","affiliation":[{"name":"Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-3949","authenticated-orcid":false,"given":"Huajun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yu","sequence":"additional","affiliation":[{"name":"WuHan Jinyintan Hospital, 430023 Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0464-544X","authenticated-orcid":false,"given":"Jieming","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;"},{"name":"National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;"},{"name":"Institute of Respiratory Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8718-8506","authenticated-orcid":false,"given":"Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;"},{"name":"National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;"},{"name":"Institute of Respiratory Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8492-1963","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Department of Gastroenterology, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, 200018 Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Meng","sequence":"additional","affiliation":[{"name":"National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co. 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