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By combining a unique RVF epidemic dataset covering both livestock and human data in a closed ecosystem (Mayotte island) with a dynamic model, we estimate viral transmission potential among livestock, and from livestock to humans. We also quantify the impact of vaccination in decreasing the epidemic size. We demonstrate that reactive livestock vaccination is key. We present a reference case study for RVF and illustrate the value of a One Health quantitative approach to surveillance and control of zoonotic infectious diseases.<\/jats:p>","DOI":"10.1073\/pnas.2004468117","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T20:26:46Z","timestamp":1600115206000},"page":"24567-24574","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":40,"title":["Estimation of Rift Valley fever virus spillover to humans during the Mayotte 2018\u20132019 epidemic"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-196X","authenticated-orcid":false,"given":"Rapha\u00eblle","family":"M\u00e9tras","sequence":"first","affiliation":[{"name":"INSERM, Sorbonne Universit\u00e9, Institut Pierre Louis d'\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (Unit\u00e9 Mixte de Recherche en Sant\u00e9 1136), 75012 Paris, France;"},{"name":"Centre de Coop\u00e9ration Internationale en Recherche Agronomique pour le D\u00e9veloppement, UMR Animal, Sant\u00e9, Territoires, Risques, et \u00c9cosyst\u00e8mes, Campus International de Baillarguet, 34398 Montpellier, France;"},{"name":"Animal, Sant\u00e9, Territoires, Risques, et \u00c9cosyst\u00e8mes, I site Montpellier Universit\u00e9 d'Excellence (I-MUSE), Centre de Coop\u00e9ration Internationale en Recherche Agronomique pour le D\u00e9veloppement, Institut national de recherche pour l'agriculture, l'alimentation et l'environnement, 34398 Montpellier, France;"},{"name":"Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9179-2917","authenticated-orcid":false,"given":"W. 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