{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:29:27Z","timestamp":1793316567514,"version":"4.5.0"},"reference-count":22,"publisher":"National Academy of Sciences","issue":"20","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Science and Technology of Anhui Province and Health Commission of Anhui Province","award":["202004a07020001"],"award-info":[{"award-number":["202004a07020001"]}]},{"name":"the China National Center for Biotechnology Development 175","award":["2020YFC0843800"],"award-info":[{"award-number":["2020YFC0843800"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,5,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>In patients with coronavirus disease 2019, a large number of T lymphocytes and mononuclear macrophages are activated, producing cytokines such as interleukin-6 (IL-6), which bind to the IL-6 receptor on the target cells, causing the cytokine storm and severe inflammatory responses in lungs and other tissues and organs. Tocilizumab, as a recombinant humanized anti-human IL-6 receptor monoclonal antibody, can bind to the IL-6 receptor with high affinity, thus preventing IL-6 itself from binding to its receptor, rendering it incapable of immune damage to target cells, and alleviating the inflammatory responses.<\/jats:p>","DOI":"10.1073\/pnas.2005615117","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T19:55:17Z","timestamp":1588190117000},"page":"10970-10975","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1947,"title":["Effective treatment of severe COVID-19 patients with tocilizumab"],"prefix":"10.1073","volume":"117","author":[{"given":"Xiaoling","family":"Xu","sequence":"first","affiliation":[{"name":"Respiratory and Critical Care Medicine, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui 230000, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6646-8085","authenticated-orcid":false,"given":"Mingfeng","family":"Han","sequence":"additional","affiliation":[{"name":"Respiratory and Critical Care Medicine, Anhui Fuyang Second People\u2019s Hospital, Fuyang, Anhui 230000, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Li","sequence":"additional","affiliation":[{"name":"Respiratory and Critical Care Medicine, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui 230000, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Respiratory and Critical Care Medicine, Anhui Fuyang Second People\u2019s Hospital, Fuyang, Anhui 230000, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6409-5366","authenticated-orcid":false,"given":"Dongsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Respiratory and Critical Care Medicine, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui 230000, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binqing","family":"Fu","sequence":"additional","affiliation":[{"name":"Institute of Immunology and the Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui 230000, People\u2019s Republic of China;"},{"name":"Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230000, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Immunology and the Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui 230000, People\u2019s Republic of China;"},{"name":"Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230000, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Immunology and the Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui 230000, People\u2019s Republic of China;"},{"name":"Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230000, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2709-6423","authenticated-orcid":false,"given":"Yun","family":"Yang","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui 230000, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyong","family":"Li","sequence":"additional","affiliation":[{"name":"Hemodialysis Center, Anhui Fuyang Second People\u2019s Hospital, Fuyang, Anhui 236000, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Respiratory and Critical Care Medicine, Anhui Fuyang Second People\u2019s Hospital, Fuyang, Anhui 230000, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Pan","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui 230000, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Immunology and the Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui 230000, People\u2019s Republic of China;"},{"name":"Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230000, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006698"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409608102"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70690-X"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","unstructured":"A. E. Gorbalenya . Severe acute respiratory syndrome-related coronavirus: The species and its viruses\u2014a statement of the Coronavirus Study Group. https:\/\/doi.org\/10.1101\/2020.02.07.937862 (11 February 2020).","DOI":"10.1101\/2020.02.07.937862"},{"key":"e_1_3_3_5_2","unstructured":"World Health Organization WHO Director-General\u2019s remarks at the media briefing on 2019-nCoV (2020). https:\/\/www.who.int\/dg\/speeches\/detail\/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020. Accessed 11 February 2020."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30154-9"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_3_3_8_2","first-page":"e201585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China","author":"Wang D.","year":"2020","unstructured":"D. Wang ., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA, e201585 (2020).","journal-title":"JAMA"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30079-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2012.10.008"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.055533-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30076-X"},{"key":"e_1_3_3_14_2","first-page":"nwaa041","article-title":"Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients","author":"Zhou Y.","year":"2020","unstructured":"Y. Zhou ., Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. Natl. Sci. Rev., nwaa041 (2020).","journal-title":"Natl. Sci. Rev."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2013.12.002"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.05.024"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57158"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2012.01.001"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60454-7"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60250-0"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000160"},{"key":"e_1_3_3_22_2","unstructured":"Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (7th Interim Edition). China NHCOTPSRO. http:\/\/www.nhc.gov.cn\/yzygj\/s7653p\/202003\/46c9294a7dfe4cef80dc7f5912eb1989\/files\/ce3e6945832a438eaae415350a8ce964.pdf. Accessed 3 March 2020."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2005615117","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2005615117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T07:13:06Z","timestamp":1649833986000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2005615117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,29]]},"references-count":22,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2020,5,19]]}},"alternative-id":["10.1073\/pnas.2005615117"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2005615117","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737846545.793575082","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.737846545.793577023","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,29]]},"assertion":[{"value":"2020-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}