{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:19:09Z","timestamp":1791357549529,"version":"4.3.1"},"reference-count":114,"publisher":"National Academy of Sciences","issue":"12","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01MH080957"],"award-info":[{"award-number":["R01MH080957"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French Ministry of Health","award":["PHRC 070138"],"award-info":[{"award-number":["PHRC 070138"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,3,23]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Genetic markers in\n                    <jats:italic>TRANK1<\/jats:italic>\n                    gene and its vicinity have been weakly associated with bipolar disorder and schizophrenia (10% increased risk). We found that the same polymorphisms are associated with Kleine-Levin syndrome (50% increased risk), a rare sleep disorder characterized by recurrent episodes of severe hypersomnia and cognitive abnormalities. Response to lithium treatment is suggestive of a pathophysiological overlap between KLS and bipolar disorder. The study also shows that variants in the\n                    <jats:italic>TRANK1<\/jats:italic>\n                    gene region may predispose to KLS when patients have had a difficult birth, suggesting that\n                    <jats:italic>TRANK1<\/jats:italic>\n                    gene region modulates newborns\u2019 response to brain injury, with consequences for mental and neurological health in adulthood. Another possibility may be that the polymorphism impacts birth and KLS.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2005753118","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T15:55:17Z","timestamp":1616082917000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":47,"title":["Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the\n                    <i>TRANK1<\/i>\n                    gene loci"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8462-3552","authenticated-orcid":false,"given":"Aditya","family":"Ambati","sequence":"first","affiliation":[{"name":"Center for Sleep Sciences and Medicine, Stanford University School of Medicine, Palo Alto, CA 94304;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Hillary","sequence":"additional","affiliation":[{"name":"Center for Sleep 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