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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,12,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Epigenetic regulations control the accessibility of transcription factors to their target regions. Modulation of chromatin accessibility determines which transcripts to be expressed and therefore, defines cell identity. Chromatin modulation during cell fate determination involves a complex regulatory network, yet the comprehensive view remains to be explored. Here, we provide a global view of chromatin accessibility during muscle stem cell activation. We identified a long noncoding RNA (lncRNA),\n                    <jats:italic>LncMyoD<\/jats:italic>\n                    , which regulates lineage determination and progression through modulating chromatin accessibility. Functional analysis showed that loss of\n                    <jats:italic>LncMyoD<\/jats:italic>\n                    strongly impairs reprogramming of fibroblasts into myogenic lineage and causes defects in muscle stem cell differentiation. Our findings provide an epigenetic mechanism for the regulation of muscle stem cell myogenic lineage progression by an lncRNA.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2005868117","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T12:51:19Z","timestamp":1607431879000},"page":"32464-32475","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":51,"title":["A long noncoding RNA,\n                    <i>LncMyoD<\/i>\n                    , modulates chromatin accessibility to regulate muscle stem cell myogenic lineage progression"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4749-889X","authenticated-orcid":false,"given":"Anqi","family":"Dong","sequence":"first","affiliation":[{"name":"Division of Life Science, Center for Stem Cell Research, Center for Systems Biology and Human Diseases, The State Key Lab in Molecular Neuroscience, The Hong Kong 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