{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:12:39Z","timestamp":1790187159146,"version":"4.1.0"},"reference-count":77,"publisher":"National Academy of Sciences","issue":"42","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000026","name":"HHS | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA037257"],"award-info":[{"award-number":["R01DA037257"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"HHS | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["S1-R01DA037257"],"award-info":[{"award-number":["S1-R01DA037257"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"HHS | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21DA044486"],"award-info":[{"award-number":["R21DA044486"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F99NS108543"],"award-info":[{"award-number":["F99NS108543"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/19284-0"],"award-info":[{"award-number":["2017\/19284-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,10,20]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Achieving abstinence is difficult for individuals with cocaine use disorder but the greater challenge is avoiding relapse. Relapse vulnerability is provoked by exposure to drug-associated cues that evoke drug craving. Cue-induced drug craving persists during prolonged abstinence and is mediated by neuroadaptations in the brain. We found that activin A is increased in the dorsal hippocampus (DH) during prolonged, but not acute, abstinence and regulates phosphorylation of NMDA receptor subunit GluN2B. Both activin A and GluN2B-containing NMDA receptors in the DH regulate cocaine seeking during prolonged abstinence. Hippocampal synaptic strength is increased during prolonged abstinence and DH projections to lateral septum regulate cocaine seeking. Together, the DH acquires an abstinent-dependent role in regulating cocaine seeking during prolonged abstinence.<\/jats:p>","DOI":"10.1073\/pnas.2006133117","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T20:31:45Z","timestamp":1601929905000},"page":"26460-26469","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":45,"title":["Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8387-777X","authenticated-orcid":false,"given":"Craig T.","family":"Werner","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY 14214;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swarup","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY 14214;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Auerbach","sequence":"additional","affiliation":[{"name":"Center for Hearing and Deafness, The State University of New York at Buffalo, Buffalo, NY 14214;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY 14214;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-1319","authenticated-orcid":false,"given":"Jennifer A.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY 14214;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-3927","authenticated-orcid":false,"given":"Andrew F.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY 14214;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-6047","authenticated-orcid":false,"given":"Pedro H.","family":"Gobira","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY 14214;"},{"name":"Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil 14040;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madoka","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY 14214;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunna","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY 14214;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moriah M.","family":"Cobb","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY 14214;"},{"name":"Department of Psychology, California State University Bakersfield, Bakersfield, CA 93311;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0577-733X","authenticated-orcid":false,"given":"Aaron","family":"Caccamise","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY 14214;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9061-8602","authenticated-orcid":false,"given":"Richard J.","family":"Salvi","sequence":"additional","affiliation":[{"name":"Center for Hearing and Deafness, The State University of New York at Buffalo, Buffalo, NY 14214;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael L.","family":"Neve","sequence":"additional","affiliation":[{"name":"Gene Delivery Technology Core, Massachusetts General Hospital, Cambridge, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy M.","family":"Gancarz","sequence":"additional","affiliation":[{"name":"Department of Psychology, California State University Bakersfield, Bakersfield, CA 93311;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6927-9236","authenticated-orcid":false,"given":"David M.","family":"Dietz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Program in Neuroscience, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY 14214;"},{"name":"Department of Psychology, The State University of New York at Buffalo, Buffalo, NY 14260"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3111"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1393-2"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.2181"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.2110"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1860-4"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/35084134"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-02-00798.2000"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.39"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12179"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029369"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001187"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018514108"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300579"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06889.x"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.175"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204622"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.144"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.217"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05674.x"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.2273111"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1700-7"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000340"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4036"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.04.020"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.07.013"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep43658"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2003.11.015"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00056"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.12.012"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay0351"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1470-6"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2014.01.002"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22185"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2106159"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.2144\/05393PS01"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00645-7"},{"key":"e_1_3_4_37_2","first-page":"1285","article-title":"Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro","volume":"283","author":"Fischer G.","year":"1997","unstructured":"G. Fischer ., Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J. Pharmacol. Exp. Ther. 283, 1285\u20131292 (1997).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1242\/bio.043554"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010500"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20985"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.06.027"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.78"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2010.06.003"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.81404"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.01.013"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.09.032"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2412-17.2018"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.02.012"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw8806"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0537-6"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.06.001"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.04.009"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0024-19.2019"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.16659010"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M604959200"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2012.02371.x"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.05.001"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.042192.116"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.06.027"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2637-9"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep06876"},{"key":"e_1_3_4_62_2","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G.","year":"2009","unstructured":"G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, (Elsevier, Burlington, MA, 2009)."},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4093-14.2015"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09627"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001869"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07088.x"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3214"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.01.021"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0773-16.2016"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4481"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0219-16.2016"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0345-17.2018"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2873-17.2018"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/312716a0"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.4.1291"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1291-15.2016"},{"key":"e_1_3_4_77_2","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988","unstructured":"J. Cohen, Statistical Power Analysis for the Behavioral Sciences, (Lawrence Earlbaum, Hillsdale, New Jersey, 1988)."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2006133117","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2006133117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T07:20:22Z","timestamp":1649834422000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2006133117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,5]]},"references-count":77,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2020,10,20]]}},"alternative-id":["10.1073\/pnas.2006133117"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2006133117","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,5]]},"assertion":[{"value":"2020-10-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}