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U.S.A."],"published-print":{"date-parts":[[2020,10,13]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Human coronavirus OC43 arose relatively recently, presumably from a bovine coronavirus spillover. Both viruses use 9-\n                    <jats:italic>O<\/jats:italic>\n                    -acetylated sialoglycans as receptors to which they attach via spike protein S. Another envelope protein, hemagglutinin-esterase (HE), serves as a receptor-destroying enzyme. We demonstrate that HE and S are functionally intertwined and that receptor destruction and receptor binding need to be carefully balanced for efficient (pre)attachment. During early emergence of OC43 this balance was reset, presumably as an adaptation to the human host. Such a two-protein mechanism for dynamic virion attachment is unique among coronaviruses, but reminiscent of that of influenza A viruses. Apparently, general principles fundamental to virion\u2013sialoglycan interactions prompted convergent evolution of two zoonotically-relevant groups of pathogens.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2006299117","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T17:25:39Z","timestamp":1601400339000},"page":"25759-25770","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":90,"title":["Coronavirus hemagglutinin-esterase and spike proteins coevolve for functional balance and optimal virion avidity"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8179-6471","authenticated-orcid":false,"given":"Yifei","family":"Lang","sequence":"first","affiliation":[{"name":"Virology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7114-762X","authenticated-orcid":false,"given":"Wentao","family":"Li","sequence":"additional","affiliation":[{"name":"Virology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeshi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CG Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Koerhuis","sequence":"additional","affiliation":[{"name":"Virology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur C. 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