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Further understanding of the cellular mechanisms contributing to the development of PD is necessary to discover therapies. Here, we characterize the role of a recently identified GWAS hit for sporadic PD, ITPKB, in the aggregation of \u03b1-synuclein, the primary pathological feature of disease. These results identify inhibition of inositol-1,4,5,-triphosphate (IP\n                    <jats:sub>3<\/jats:sub>\n                    )-mediated ER-to-mitochondria calcium release as a potential therapeutic approach for reducing neuropathology in PD.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2006476118","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T11:54:30Z","timestamp":1608724470000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":67,"title":["The Parkinson\u2019s disease-associated gene ITPKB protects against \u03b1-synuclein aggregation by regulating ER-to-mitochondria calcium release"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-4367","authenticated-orcid":false,"given":"Daniel J.","family":"Apicco","sequence":"first","affiliation":[{"name":"Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142;"},{"name":"Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Shlevkov","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1849-6038","authenticated-orcid":false,"given":"Catherine L.","family":"Nezich","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4105-9060","authenticated-orcid":false,"given":"David T.","family":"Tran","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Guilmette","sequence":"additional","affiliation":[{"name":"Gene Therapy Accelerator Unit, Biotherapeutics and Medicinal Sciences, Biogen, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin W.","family":"Nicholatos","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142;"},{"name":"Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin M.","family":"Bantle","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142;"},{"name":"Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Glajch","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta A.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan T.","family":"Dang","sequence":"additional","affiliation":[{"name":"Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7158-3405","authenticated-orcid":false,"given":"G. 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